Innovations Realized

Explore thousands of successful projects resulting from collaboration between organizations and post-secondary talent.

13270 Completed Projects

1072
AB
2795
BC
430
MB
106
NF
348
SK
4184
ON
2671
QC
43
PE
209
NB
474
NS

Projects by Category

10%
Computer science
9%
Engineering
1%
Engineering - biomedical
4%
Engineering - chemical / biological

Apelin Analog Therapy as an Innovative Treatment for Cardiovascular Diseases

Apelin, an innate peptide, is a critical component of the apelin pathway, which is responsible for regulatory mechanisms of the cardiovascular system. Apelin is downregulated in patients with cardiovascular disease, therefore limiting the cardioprotective potential of the pathway. This project focuses on the optimization of a biological analog, able to withstand enzyme degradation with improved function that acts as a substitute for apelin. The intern involved in this project will have the opportunity to be a part of the development of a conceptual pharmaceutical into a biologic that can be used in clinical practice for patient treatment. Through the completion of this internship, PEARKO Therapeutics will have the assistance it needs to fully optimize its preclinical apelin analog formulations, bringing it a step closer to use in clinical practice.

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Faculty Supervisor:

Gavin Oudit;John Ussher

Student:

Mahmoud Gheblawi

Partner:

PEARKO Therapeutics Inc.

Discipline:

Other

Sector:

Health care and social assistance

University:

University of Alberta

Program:

Accelerate

Tackling Food Insecurity through Innovations in Collaborative Food Systems Governance

Food security is a growing concern in communities across Canada, along with a host of other challenges impacting the health and equity outcomes of our food system. Municipalities, whether big or small, find themselves at the front lines of these issues and there is growing recognition of the potential for municipalities to play a leading role in addressing food security and promoting healthy sustainable food systems. At the same time, there is growing interest in developing collaborative and inclusive approaches to food policy and food governance – the relationships, rules, practices and structures through which power and control are exercised and decisions are made over how food is produced/harvested, processed, distributed and consumed. This project brings these two elements together, to explore, model and evaluate innovative approaches to municipal food governance that enable governments and civil society actors to be active partners in fighting hunger in their communities.

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Faculty Supervisor:

Amanda Wilson

Student:

Nathalie McSween

Partner:

Tides Canada

Discipline:

Sociology

Sector:

Other services (except public administration)

University:

Saint Paul University

Program:

Accelerate

Therapeutic Strategies for Restoring Palmitoylation and Autophagy in Neurodegeneration

The cellular clearance pathway autophagy is required for degrading toxic proteins and damaged organelles, but is disrupted in many neurodegenerative diseases. During induction many autophagy regulators quickly localise to membranes from the cytosol. The Martin lab has identified palmitoylation, which involves the addition of the fatty acid palmitate to cysteine residues, as a potential regulator to direct autophagy proteins to membranes. The Martin lab has confirmed that several regulators of autophagy are palmitoylated, including the key autophagy receptor p62 that tags and delivers toxic substrates to lysosomes for degradation. p62 palmitoylation was significantly decreased in brains of Huntington disease (HD) patients and an HD mouse model suggesting that decreased p62 palmitoylation may lead to the impaired cargo loading seen in HD cells. Therefore, rescuing p62 palmitoylation may represent a therapeutic target for HD.

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Faculty Supervisor:

Dale Martin

Student:

Firyal Ramzan

Partner:

Circumvent Pharmaceuticals Inc

Discipline:

Biology

Sector:

Manufacturing

University:

University of Waterloo

Program:

Building ecologically robust lakes for offsetting fisheries productivity – part 2

Canada is among the world’s largest producers of energy derived from resource extraction. Canada’s Oil Sands Region produces 70% of Canada’s crude oil, and ranks third, after Saudi Arabia and Venezuela, in terms of proven global crude oil reserves. In order for Canadian industry to continue to meet this high demand for energy they must adhere to the social and environmental pressures to reclaim and restore the extraction sites to their original condition, and to offset potential environmental destruction. Offsetting is a key component of Canada’s Fisheries Protection Policy under the Fisheries Act. When habitat that is deemed is destroyed, and mitigation is not possible; offsetting measures are required to ensure No Net Loss in fisheries productivity. The Fisheries Act (s 6.1) enshrined offsetting measures into law, with the goal of “sustained yield of one or all … fish species that comprise a fishery in a specified fishing area (Randall et al. 2013)”; including “sustained productivity, as experienced by participants in the fishery at and just before the time of interest (Randall et al. 2013)”.

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Faculty Supervisor:

Mark Poesch

Student:

Karling Roberts;Sebastian Theis

Partner:

Canadian Natural Resources Ltd.

Discipline:

Resources and environmental management

Sector:

University:

University of Alberta

Program:

Accelerate

The Role of Natural Background Radiation on Neurological Development and Processes

All species on the planet are affected by their environment: temperature, atmospheric pressure, daylight hours, and so on. These conditions affect how a species react to stress, grow, reproduce, and survive. Natural background radiation (NBR) is ever-present and has been prior to the evolution of all species. In order to study the effect of NBR on important biological processes, such as brain growth and development, we must remove it from the environment to see if it induces any changes. In order to remove NBR, a deep underground laboratory, shielded from NBR exposure must be used. This research will be important to science and radiation-relevant industries as it will produce previously unknown knowledge about NBR and how it affects the brain and behaviour.

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Faculty Supervisor:

Sujeenthar Tharmalingam

Student:

Christine Lalonde

Partner:

Nuclear Innovation Institute

Discipline:

Biochemistry / Molecular biology

Sector:

Other

University:

Laurentian University

Program:

Accelerate

Towards a Theory of Blockchain as a Socio-Informational-Technical System

Blockchains operate as perhaps the most promising system of trust for any type of digital transaction of value — everything from cryptocurrencies to patient medical records. But a number of barriers — involving social institutions, data and identity management and technological processes — stand in the way of broader adoption. These challenges also ultimately speak to fundamental issues of trust and perceived legitimacy on the part of both service providers and their end users. This project intends to advance the state of the art in all three areas to reduce if not eliminate the barriers to broader adoption. The partner organizations involved in this project are all working to integrate blockchain in their processes and expect to significantly advance their efforts through the fruits of this research.

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Faculty Supervisor:

Victoria Lemieux;Harish Krishnan;Ning Nan;Zehua Wang;Chen Feng;Ivan Beschastnikh;Alexandra Fedorova

Student:

Artemij Voskobojnikov;Danielle Alves Batista;Dingan (Derek) Chen;Fangyu Gai;Hoda Hamouda;Hassan Packir;Darra Hofman;Zachary Zabawa

Partner:

Boehringer-Ingelheim Canada Ltd

Discipline:

Engineering - computer / electrical

Sector:

Health care and social assistance

University:

University of British Columbia

Program:

Accelerate

Cognitive Powertrain and Metaveillogrammetric sensing for transportation

There is massive growth in the area of smart cities (e.g. sensors in streetlights), smart cars, and “smart people” (sensors on people, e.g. wearable computing). In some cities like San Diego, there are cameras and microphones in nearly every streetlight in the downtown core area. Most cars made now have one or more cameras in them, and numerous other kinds of sensors are being invented. These sensors are important regarding autonomous vehicles as well as technologies for extended human intelligence and safety. We will research sensing and metasensing (the sensing of sensing) and develop new forms of sensing (camera-based sensing as well as phasecoherent sensing with active vision like sonar, and other sensors), and meta-sensing. Whereas there exists a large body of research on quantification of physical quantities like sound and light (e.g. illumination standards), the quantification of sensing has not been explored to the same degree.

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Faculty Supervisor:

Steve Mann

Student:

Phillip Vinh Do;Danson Evan Lu Garcia;Jesse Hernandez

Partner:

Ford Motor Company

Discipline:

Engineering - computer / electrical

Sector:

Manufacturing

University:

University of Toronto

Program:

Accelerate

Bioorthogonal spin labeling approaches for high sensitivity electron paramagnetic resonance spectroscopy

In order to investigate proteins in their natural environment one can attach tiny reporter molecules to them that can be traced with appropriate instruments. However, these small reporter molecules may often cause strong perturbations to the functionality of the proteins, or cannot be seen due to experimental restrictions like low concentrations. Bioorthogonal chemistry aims to eliminate such experimental restrictions by using as inert molecules as possible to see how proteins really work. We want to test novel bioorthogonal strategies for attaching reporter molecules that can be detected with electron paramagnetic resonance (EPR) spectroscopy, a powerful magnetic resonance method that is able to detect changes in structure and function of proteins. As we also have a unique and highly sensitive, state-of-the-art EPR device at hand, together with new bioorthogonal strategies we are convinced that we will bridge the gap to a new world of applications.

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Faculty Supervisor:

Oliver Ernst;Cordula Enenkel

Student:

Joerg Reichenwallner;Fraser Ferens

Partner:

High Q Technologies LP

Discipline:

Biochemistry / Molecular biology

Sector:

Manufacturing

University:

University of Toronto

Program:

The interplay between mental health, mental illness, sport culture, and athletic performance in Olympic and Paralympic sport

Mental health is increasingly being recognized as a key component of elite athletes’ overall functioning and sport performance. Globally, research on antecedents (e.g., sport culture) and consequences (e.g., athletic performance) of mental health and illness in elite athlete populations is growing. However, little is known about the relationship between mental health, mental illness, sport culture, and athletic performance in the Canadian high-performance sport context. The purpose of this research project is to better understand the interplay between these variables in Canadian Olympic and Paralympic athletes using a longitudinal mixed-methods design. The results and deliverables associated with this project will help the partner organization, Own The Podium, develop evidence-based and culturally appropriate resources, policies, and programming to support Olympic and Paralympic athletes in their training and competition environments.

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Faculty Supervisor:

Natalie Durand-Bush;Michelle Dionne

Student:

Krista Van Slingerland;Rachel Jewett;Connor Primeau

Partner:

Own the Podium

Discipline:

Kinesiology

Sector:

Arts, entertainment and recreation

University:

Program:

Accelerate

Investigation and development of strategies for performing constrained inversions of geophysical data for mineral exploration

Geophysical inversion is the process of determining a 3D computer model of the Earth’s subsurface from measurements made in a geophysical survey. Geophysical data are sensitive to the presence, location and size of certain rock types including ore bodies. However, many different rock types can give similar measurements, and the measurements are usually sensitive to only large-scale variations in the subsurface. To mitigate these shortcomings, it is possible to incorporate additional information into the inversion process. For example, the
locations of particular rock types (known from geological mapping or borehole logging) can be used to force the Earth model constructed by inversion to be correct at these locations. If portions of the model are correct then the remainder of the model is more likely to be correct. Techniques and software exist for performing this kind of “constrained” inversion. However, not much work has yet been done to determine the most effective way of incorporating the additional information into these inversions. This is what will be done in this research project.
The partner organization is active in mineral exploration and has previously used default, unconstrained inversion methods.

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Faculty Supervisor:

Colin Farquharson

Student:

Mehrdad Darijani

Partner:

Vale Canada Limited

Discipline:

Geography / Geology / Earth science

Sector:

University:

Memorial University of Newfoundland

Program:

Hydrogen Production From Utility-Scale Electrolysis for Fuel Cell Electric Bus Supply in Ontario

Hydrogen Fuel Cell technology is actively pursued as a viable, sustainable and long-term solution for resolving transportation-related emission issues on a global scale. While Canada has a strong presence in this technology space in various parts of the world such as Europe, the USA, and China, hydrogen technology integration at the transit level is still not a reality in this country. CUTRIC’s leadership through the Pan-Canadian Hydrogen Fuel Cell Electric Vehicle Demonstration & Integration Trial Phase I is enabling Canada to regain its leadership in hydrogen technology innovation by utilizing electrolytic hydrogen as a fuel source. This proposed research project aims to evaluate the technical and economic challenges and opportunities to electrify Ontario’s transit bus networks using hydrogen fuel cell electric buses (FCEBs). The production and storage of hydrogen in Ontario from large-scale power-to-gas technologies will be investigated in order to supply the required hydrogen to power FCEBs. Several models will be tailored and/or developed in this project to study the technical and economic feasibility related to the production of hydrogen to supply FCEBs in Ontario.

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Faculty Supervisor:

Hany Farag

Student:

Nader El-Taweel;Gouri Barai;Abdullah Sawas;Abdullah Al-Obaidi

Partner:

Canadian Urban Transit Research and Innovation Consortium

Discipline:

Engineering - computer / electrical

Sector:

Professional, scientific and technical services

University:

York University

Program:

Accelerate

Innovations in Collaborative Food System Governance

Food security is a growing concern in communities across Canada, along with a host of other challenges impacting the health and equity outcomes of our food system. Municipalities, whether big or small, find themselves at the front lines of these issues and there is growing recognition of the potential for municipalities to play a leading role in addressing food security and promoting healthy sustainable food systems. At the same time, there is growing interest in developing collaborative and inclusive approaches to food policy and food governance – the relationships, rules, practices and structures through which power and control are exercised and decisions are made over how food is produced/harvested, processed, distributed and consumed. This project brings these two elements together, to explore, model and evaluate innovative approaches to municipal food governance that enable governments and civil society actors to be active partners in fighting hunger in their communities.

View Full Project Description
Faculty Supervisor:

Amanda Wilson

Student:

Nathalie McSween

Partner:

Discipline:

Sociology

Sector:

Other services (except public administration)

University:

Saint Paul University

Program:

Accelerate

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