Lithium-sulfur (Li-S) batteries have been considered as one of the most promising candidates to meet the energy storage demand for electric vehicles due to their high theoretical energy density of 2600 Wh kg-1, low cost, natural abundance, environmental friendliness. State-of-the-art Li-S batteries, using liquid electrolytes, still have significant challenges in their safety and lifespan. Accordingly, […]

Thermal stress analysis of the buried pipeline is an integral part of pipeline design and integrity analysis. Pipeline design code (e.g. CSA Z662) provides guidance on the thermal stress analysis of restrained and unrestrained pipe sections. However, a buried pipeline bend is more likely to be partially restrained, as the pipe is free to expand […]

Emerging therapeutic agents that function through the brain’s neurotransmitter systems have recently shown robust benefits in a number of otherwise challenging to treat neurological conditions including depression and post-traumatic stress disorder. The long-term changes that these agents induce within neural tissue is still however unclear. This MITSCS program aims to to use expertise in tissue […]

The progression of bacterial antimicrobials resistance (AMR) has led us to an era that urgently requires alternative antimicrobial therapies. Metal-based antimicrobials (MBA) are increasingly seen as part of the solution. Several metals are already extensively used to prevent and treatment of infections. Silver/copper ionizers are presently used to control pathogens in Canadian hospital water distributions […]

Large amounts of sewage sludge (SS) have been generated yearly by municipal wastewater treatment plants (WWPs), which entail huge operational expenses and advanced treatments, and the final disposal of biosolids in agricultural applications is reduced because of the potential environmental risks (e.g., heavy metals and emerging contaminants) associated with biosolids applications. The increased use of […]

Fungal pathogens cause life-threatening invasive infections in humans. Despite all available treatments, mortality rates remain unacceptably high, on par with deaths caused by infectious diseases such as tuberculosis and malaria. Alarmingly, the emergence of drug-resistant fungi is reducing already limited treatment options. To address needs for new antifungal medications, Amplyx Pharmaceuticals has developed fosmanogepix, a […]

Anxiety disorders and chronic stress represent major healthcare and economic burdens worldwide. Approximately 75% of Canadians who use health services for a mental illness present with anxiety disorders which may affect up to 10% of the population in terms of lifetime occurrence. Despite the large prevalence of anxiety-related disorders in Canada, there are currently a […]

In this project, an oncolytic virus will be generated that combines the safety profile of vaccinia virus, with the immunostimulatory power of RNA-vaccines. Currently, the RNA-genomes of Alphaviruses are successfully used to encode proteins to be vaccinated against. Their special genome organization and makeup allow them to self-amplify within a cell. This replication in turn […]

One rapidly evolving area of cancer therapeutics is immunotherapy, which aims to drive a cancer-targeted immune response in tumors. Replicating virus-based therapeutics are a novel cutting-edge immunotherapy that have shown promise clinically. Turnstone Biologics has developed a novel cancer-killing virus with the capacity to deliver multiple payloads to further enhance the virus’ anti-cancer effects in […]

Oncolytic viruses (OVs) are promising biotherapeutics that selectively infect and kill cancer cells. The efficacy of oncolytic viral therapy depends on the virus’s efficient replication and dissemination within tumors. However, tumors often develop a dense extracellular matrix (ECM) surrounding their cells that provides resistance against many forms of cancer therapies including OVs. To overcome this […]

Through engineering and selection strategies, we have created novel cancer-killing oncolytic viruses (OVs) that are selective for tumours but are unable to grow in normal tissues. A critical component of the therapeutic activity of this class of therapeutics is the induction of an anti-tumour immune response, which can be suppressed in many tumours. One strategy […]

The purpose of this project is to add a feature to Rentrax so that business owners can track the physical location of their rental items. Device should be small enough to be hidden in rental items such as bikes. Battery usage of device should be as low as possible so that it doesn’t need frequent […]