The purpose of this project will be to develop a flexible and statistically sound methodology for leveraging BPI’s database of current and historical publicly available coverage information to model coverage trends in the U.S. health insurance industry. The project will also include the development of an R Markdown template for future predictive analytics reports. The […]

Genacol Canada Corporation Inc. manufactures a bovine-sourced hydrolyzed collagen supplement (Genacol® Original Formula), which has shown efficacy in two separate clinical trials for reducing joint pain. Following digestion, hydrolyzed collagen yields amino acids and peptides that can lead to the health promoting properties of the supplement. However, the specific identity and mechanisms of action of […]

Castration-resistant prostate cancer is a late stage disease and many people die of it due to lack of effective therapeutic drugs. In the current project, we propose to develop new therapeutic drug a to specifically target CRPC’s common weak points, which are MCT4 and eIF4E gene’s proteint products that play very important roles in regulation […]

A novel technology for delivery of biologically active compounds found in hemp oil is being developed. This novel technology significantly reduces the health risks associated with traditional administration of Cannabis products (e.g., smoking and THC-related intoxication) The proposed project, in collaboration with a federally-licensed facility for cannabinoid analysis, Abattis Bioceuticals, engages into the development of […]

Alzheimer’s disease (AD) is an age-related neurodegenerative disease affecting more than >45 million individuals worldwide with numbers expected to reach >135 million by 2050. The multifactorial nature of AD hinders the development of therapeutic treatments and, as such, several drug candidates have failed in clinical trials. Polyphenolic compounds have the ability to reach the brain […]

One aspect of modern drug development involves understanding how enzymes function in terms of the progress of certain diseases in humans. This MITACS project involves the synthesis of small-molecule labels that can bind to a specific enzyme of interest, so as to better understand the mode of action of this enzyme as related to the […]

Pertussis, also known as whooping cough, is a contagious bacterial disease that targets cells in the human respiratory tract. Whooping cough is an airborne disease that causes coughing fits, difficulty breathing and potentially death. Although it can be life threatening, the disease is preventable with proper immunization. Pertactin is a commonly used protein derived from […]

This collaboration between pharmaceutical company NuvoBio and a Research Team led from the University of Windsor and working with Dalhousie and the University of Western Ontario seeks to develop a new vaccine for lung cancer. The students and postdoctoral fellows will be making new types of molecules and investigating some underlying questions about how we […]

Our group developed a new generation of chip-based small-scale devices for continuous purification of chemicals and nanoparticles, based on the interactions of analyte with multiple types of driving forces in an electro-fluid-dynamic (EFD) system. One series of the purification devices has the electric field in parallel with the fluid flow direction (E?F), while the other […]

Preterm neonates ill-adapted to the extra uterine environment are prone to increased inflammation in multiple organs and the proinflammatory interleukine IL-1b has been closely implicated in brain injury associated with preterm birth (PTB). Notably, PTB survivors have a greater propensity to develop ischemic brain lesions long after birth. Here, we hypothesize that the neural vasculature […]

The molecular mechanisms responsible for the occurrence of metastatic cancer are beginning to be elucidated with the identification of key regulators. Increasing evidence points to tumor cell epithelial to mesenchymal transition (EMT) as an important contributing process to metastatic evolution. The identification of factors that are stimulated during EMT might provide the means to develop […]

More children die from brain cancer than from any other disease in the western world. Many anti-cancer drugs are unable to cross the blood-brain barrier to reach the tumor and certain genetic mutations in the tumor cells increase resistance to chemotherapeutics. The novel chemotherapeutic drug VAL-083 readily crosses the blood-brain barrier and accumulates in brain […]