The intern will use screening methods to define which gene which are altered in the Jurkat human T cell line following incubation with the Verotoxin B subunit as a means to define the potential mechanism by which this treatment protects these cells from HIV1 infection in vitro. LISI Therapeutics will benefit by increasing their license […]

Diabetes is a serious, common and chronic health problem. In Canada, more than 2 million Canadians are living with diabetes today. Type 2 diabetes is the most common type of diabetes that accounts for approximately 90% of diabetes cases. The cost of diabetes care is almost 4 times as much as for someone without diabetes. […]

Vitamin D compounds are being developed for the treatment of chronic kidney disease. The purpose of this proposal is to develop a cell-based screening platform that will allow the rapid assessment ofrelative efficacy of a library of compounds. The intern will use recombinant DNA methodology to generate a cell-based assay in which the green fluorescence […]

Optimal control problems and reaction-diffusion systems have many applications in pharmaceutical research.  For instance, the enzymatics collagen matrix degradation and the principal process governing drug transport inside a solid tumor could both be described by reaction-diffusion systems.  Solving these systems using effective numerical algorithms will benefit drug product design, drug delivery and cancer treatment.  Since […]

The goal of the current research is to design an injectable polymer-lipid (Pol.i) formulation to treat ovarian cancer. The PoLi drug delivery system is a hiocompatible and biodegradable, physically cross-linked gel that has the potential to provide dramatic improvements in the treatment of ovarian cancer. It is formulated as an injectable gel (all components are […]

Solid pharmaceutical dosage forms such as tablets and beads used in capsules are currently coated by liquid coating technology, which incurs high environmental risk and high capital and operation costs. Prof. Zhu's research group has developed an ultratine powder coating technology for the auto industry. Our previous studies have shown that the same technology can […]

The high throughput combinatorial testing for pharmaceutical applications requires fast methods for manipulating droplets in microfluidic systems. In this project, a microwave platform will be designed and employed for fast droplet heating, identification and detection. The use of extremely confined microwave energy makes heating, detecting, and identifying droplets possible. With the new platform it will […]

In this project we analyze how a government healthcare provider should negotiate a risk-sharing contract with pharmaceutical drug manufacturers. The objective of the study is to examine how a government healthcare payer should set the terms of pay-for-performance contracts with multiple drug or pharmaceutical manufacturers. The study builds on existing work by Mahjoub, Odegaard, and […]

  After pharmaceutical products are released into the market, a number of statistical methods are used to monitor the adverse effects of these drugs. If a large enough number of incidences are reported to regulatory bodies, appropriate measures are taken. This research project is dealing with the statistical methods used to decide on how many reports is required before […]

  Arthritis is a debilitating disorder characterized by chronic inflammation and persistent pain. This project aims to uncover ways of reducing the pain and discomfort felt by people afflicted by this disorder.  A number of key points will be addressed through this project. Firstly, we will gain a better understanding of the possible neurological component […]

  In recent years, the interest given to disease biomarkers has boomed. Biotechnology and pharmaceutical companies are exploring ways to use biomarkers to speed up the drug development process, as well as to rapidly assess a diseases state, staging, progression and response to therapy. Multiple reaction monitoring (MRM) Mass Spectrometry (MS) has been shown to […]

  Since the beginning of the epidemic, HIV has killed more than 25-million people worldwide. Highly active antiretroviral therapy (HAART), which was introduced in 1996, has revolutionized HIV treatment, by improving health, life expectancy, and dramatically reducing transmission of HIV to others. The British Columbia Centre for Excellence in HIV/AIDS played a leading role in […]