Development and use of ezrin biosensors for high-throughput screening of novel ezrin inhibitors as anti-metastatic and immune-checkpoint blockade agents

Treatment of metastatic breast cancer is often unsuccessful and lead to 5000 deaths in Canada each year. Therefore, there is an unmet need for new drugs for prevention and/or treatment of metastatic disease. Ezrin is a protein marker commonly over-expressed in metastatic breast cancer. Preclinical studies show that blocking ezrin can significantly reduce metastasis in […]

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Developing ‘all-natural’ approaches to food-grade Malic acid production

Malic acid is a naturally-occurring chemical found in fruits such as blueberries, apples, cherries and grapes. Malic acid gives food a sour or tart taste. Because of this, it is an important food additive used to balance sweetness or salt. Examples of industrial malic acid use in snack foods are sour gummy candies and flavoured […]

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Development of a softab nutraceutical formulation

Softab Technologies is a fast-growing company in Windsor, Ontario that is developing new formulations and methods to provide nutraceuticals: vitamins, natural extracts, and minerals in a revolutionary new form of chewable and dissolvable gel. They are working with a research team in the Department of Chemistry and Biochemistry at the University of Windsor to refine […]

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OPTIMIZATION OF A HEAT TRANSFER SYSTEM

Heat exchangers, used in building heating, ventilation and air conditioning (HVAC) systems to transfer heat from hot to cold fluids, are designed to operate under ideal conditions. However, in practice operating conditions may vary with ambient temperature or humidity. HVAC system efficiency can be improved significantly if fluid flow rates are adjusted in response to […]

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Tuning the Front End: Increasing Ion Generation for Enhanced Sensitivity in Mass Spectrometry with Multiple ESI Emitters

Mass spectrometry is a chemical analysis technique for determining the mass/charge ratio of molecules under study. The instruments used for this technique require the compounds be transformed into gas-phase ions. This process is extraordinarily difficult with Nobel prizes awarded for the two most common methods. One of these methods is electrospray ionization where dissolved compounds […]

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Nutrient removal using a solid state glass adsorbent for treating agricultural waste, waters, and public effluents

Agricultural waste and public effluents often contain elevated levels of phosphorous and nitrogen that limit its ability to be directly repurposed as crop fertilizer or irrigation spray. Removal of soluble nutrients from waste water is difficult. Current treatment options have high investment costs and are often not well suited for smaller farm sizes common in […]

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Development of an innovative UV-LED based platform for horticultural applications

We are proposing an innovative platform (The Airbox) for vertical/indoor farming using UV-LED lighting. The Airbox offers a self-contained, highly controlled environment with vertical farming techniques in conjunction with hydroponic methods all in a very compact footprint. We wish to optimize the Airbox for medical Cannabis applications, and extend its applicability to other plants and […]

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Mitigation strategies for acrylamide formation in the bakery sector

Acrylamide is a food contaminant that is formed in a variety of food products upon heating. Baked cereal products are one of the most important sources of acrylamide in our daily diet. The formation of acrylamide needs to be tightly controlled, and, if possible, be avoided. This project is focusing on the effect of ingredient […]

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Voice pitch cues in speech intelligibility, prosody, and memory consolidation, for cochlear implant users

Cochlear implants are surgical devices that allow deaf people to recover some form of hearing and understand speech. However, current devices are limited, particularly in terms of their ability to transmit voice pitch information. Users have to compensate for these limitations by spending additional resources to decode words, fill-in the gaps, and extract linguistic and […]

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