Ticks contain many different disease-causing bacteria and viruses, including the bacteria that causes Lyme disease. Multiple infections with these other pathogens in addition to Borrelia cause more severe illness. For many of these pathogens there are no or limited diagnostic tools available to detect the pathogen. This project includes production of a new product, “a […]

During maturation, juvenile rats have dramatic histomorphometric changes within their tissues, including marked proliferation and cell death. These background changes should not be mistaken with drug-induced pathologic features. This is critical for optimal drug toxicity studies. The main objective of this study is to build a database on apoptosis and proliferation at different time points […]

Although life expectancy is increasingly associated with the treatment of heart disease and cancer, there has been virtually no improvement in life expectancy for patients with dementia. Dementia has a devastating impact to the patient, family members and society because patients become dependent on family caregivers, who are then less productive in other aspects of […]

Development of cancer is mainly due to uncontrolled cell growth and the proteasome is a cellular component that regulates this process. Resistance to chemotherapy is the main reason for cancer treatment failure, and therefore,there is a need for development of new and potent drugs. Recent studies have shown that proteasome inhibitors effectively inhibit growth of […]

The GeneSight (GS) Psychotropic Test (AssureRx Health, Inc.) measures individual variations in drug-related genes and recommends optimal drug choices for individual patients. A clinical study will be conducted to validate novel gene markers of antipsychotic-induced weight gain for use in an enhanced version of GS. Sarah Groleau will be responsible for genotyping DNA from 600 […]

Rabbits are increasingly recognized for their superior immune response to antigens and their ability to generate highaffinity monoclonal antibodies (mAbs) that can be used as reagents, diagnostics and therapeutics. However, methods for the discovery of rabbit mAbs are limited and extremely cumbersome. This proposal aims at developing a rapid and robust microfluidic-based approach to generate […]

Bladder Carcinoma (BC) is the fifth most common cancer in Canada. Although most individuals have surgery to remove BC tumors, the risk of another BC developing and/or progressing to invasive disease is high so long-term surveillance is necessary. The current method for screening for BC is not sensitive enough, and individuals often end up undergoing […]

The development of beneficial bacterial inoculant as biopesticide and biofertilizers is directly beneficial to agricultural producers through the preservation and enhancement of crop quality and yield. At present, a limited spectrum of naturally occurring microorganisms have been developed for directed, commercial agricultural applications in Canada. Engage Agro Corp is interested in developing bacterial inoculants with […]

Cataract surgery is one of the most common surgeries performed worldwide. The incidence of posterior capsule opacification (PCO) after cataract surgery, a serious complication that affects vision and requires additional treatment, is ~30%. In this study, we will investigate differences in PCO, presence of fibronectin, and ciliary ring distortion between lenses in eyes obtained from […]

Peanut is one of the leading foods that can cause food allergies. An extremely low amount of peanut protein is sufficient to cause mild reactions in people who are sensitive to peanut. Over 90% of allergic reaction cases derived from peanut digestion are related to Ara h 1, a glycoprotein that comprises about 15% of […]

In recent years monitoring and protection of food and water resources became a priority of governments worldwide. Bio-hazards are potential threat for these resources thus need to be addressed both in industry and in academia. Therefore, developing an accurate, fast and cost effective technique for detection of pathogenic strains called for increased demand on the […]

With a rich acoustic dataset available in the Strait of Georgia (SoG), we propose this research to develop a series of acoustic indicators of productivity for forage (e.g. Pacific herring, mesopelagic fish, euphausiids, zooplankton and ichthyoplankton) and semi-demersal (e.g. Pacific hake and walleye pollock) species within the SoG by using robust multi-frequency techniques. Along with […]