Role of 5alpha-Dihydrotestosterone and Androgen Receptor in Estrogen Receptor-Positive Breast Cancer

Breast cancer is the most frequent cancer affecting women, with 1 in 9 Canadian females expected to develop the disease in their lifetime. About 90% of estrogen receptor (ER)-positive breast cancers express androgen receptor (AR). Recent results in our laboratory demonstrated that the inactivation of 5alpha-dihydrotestosterone (DHT), the most potent androgen, contributes to estrogen-dependent breast […]

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Determining Optimal Strategies to operate Not-For Profit Health Organizations

The goal of this project is to devise a strategy for improving the operations of Canadians for Health Research (CHR) to achieve long-term prosperity. CHR is a non-profit organization (NPO) and its mission is to provide Canadians with a comprehensive understanding of the importance of health research so that they may develop an informed perspective […]

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Development of new approaches to promote proliferation of insulin producing pancreatic ?-cells in diabetic patients

Reduced number of insulin producing ?-cells in pancreas due to increased ?-cell death is a key defect in diabetes that eventually leads to elevated blood glucose levels and life-time treatment with glucose lowering drugs or daily insulin injections. Thus, finding therapeutic approaches to prevent the decrease in the number of insulin producing ?-cells in diabetic […]

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Can cats protect people from Lyme disease?

Domestication of cats is thought to date to the Neolithic and to have been driven by the need to control rodents that destroyed stored food. In developed countries, modern pest control methods have rendered the traditional role of cats largely redundant and the hunting tendency of cats is now viewed in a more negative light […]

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Coupling of DTI Imaging and Focused Ultrasound: Assessment of Targeting Accuracy and Effect of Treatment

As a novel solution for the treatment of common paediatric neurological diseases, this project aligns with goals of the Toronto General and Western Hospital Foundation of promoting surgical innovation and improving patient care. Philips Healthcare Canada has a proven track record of research and development in the healthcare industry and is able to provide research […]

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Effects of Pulse Lighting Regimes on Microalgae Growth

Algae are microorganisms present in all aquatic environments with the ability to grow using sunlight as energy source. This ability can be harnessed to produce biomass for various purposes of industrial interests such as biofuel, animal feed, nutrients, etc. This project seeks to improve the productivity of an algal growth facility while reducing energy costs […]

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White pine endophytes: improving tolerance to white pine blister rust

White pine blister rust is a serious disease of pine, an ecologically and economically important forest species in Ontario and the Maritime Provinces. In western Canada, this pathogen has virtually eliminated pine as a commercial species and the disease now threatens eastern Canada. Endophytes are fungi that live in the leaves of various plants including […]

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Biomolecular Structure Analysis to Accelerate Develoment of New Vaccines and Monoclonal Antibodies

Manufacturing of consistently high quality products is the commitment of the pharmaceutical industry. To achieve this, new products must be thoroughly tested and the results meet government-approved product specifications. Improving existing and adopting improved analytical technologies for product testing ensure the production of safe and effective products. This is particularly critical for the manufacturing of […]

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Scientific Validation of the CBI Workplace Solutions Pre-Placement Functional Assessment for Canada Post Delivery Agents

The purpose of this project is to conduct a scientific evaluation of pre-placement functional assessment for Canada Post delivery agents. Within the project, the research team will evaluate how delivery agents (letter carriers) perform mocked-up work tasks (based on actual job tasks observed in the field). Then the research team will evaluate how delivery agents […]

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