Many genetic diseases caused by small genetic mutations do not result in complete loss of protein fnction, but rather are due to the degradation of mutant protein by a “quality control” mechanism (endoplasmic reticulum-associated degradation-ERAD) soon after it is made. Prominent amongst such ERAD-dependent diseases is Cystic Fibrosis(CF), a chronic, progressive, life-threatening genetic disease that […]

The work will develop a simple blood test that will enable the detection of a valuable Natural Health Product, Curcumin, that is commonly found in Tumeric, to be detected in blood samples from only a simple finger prick. It is believed that curcumin has important medicinal effects such as anti-cancer, anti-inflammatory, and antioxidant activities. However, […]

The main objective of the project is to provide the Institut de l’OEil des Laurentides (IOL) with the capability of receiving patients from remote locations without requiring the patients to physically come to the IOL. A remote diagnostic tool would allow the IOL to improve the comfort of patients as well as expand its activities […]

Chicken egg yolk contains IgY antibodies that target various infectious disease and food allergens. IGY Inc is a company focused on utilizing chicken immune system for antibody production. Their innovative products have applications in food processing, therapeutics and diagnostics. IgY antibody contains 0.64% of total wet egg yolk and after extracting the antibodies, the leftover […]

As an important medicinal plant, Cannabis sativa produces bioactive molecules that provide symptom relief for conditions such as severe cancer pain, nausea and vomiting associated with chemotherapy. The cannabinoid biosynthetic pathway that generates bioactive molecules has been studied for over a decade. However, understanding of transcriptional regulators that control cannabinoid synthesis is fairly limited. The primary site […]

Determine how cannabinoid metabolites and their relative abundances differ among marijuana strains. Post Doctoral Fellow Name: Teagen D Quilichini Cannabinoids are synthesized and accumulate in Cannabis plant hairs called glandular trichomes, which are particularly abundant on female flower buds. Cannabinoid content and composition vary dramatically among Cannabis strains, with two general groupings distinguished: marijuana strains, […]

As the Canadian population is aging, more and more Canadians will show cognitive decline. Aging and certain types of neurological disorders is often associated with deficits in executive functions: goal maintenance, planning, task switching and attention. These functions are critical for the maintenance of functional independence. Few validated rehabilitation approaches for these types of deficits exist. One […]

B. Gosselin and Doric Lenses Inc. have developed the first low-cost wireless head mounted optogenetic device enabling simultaneous biopotential recording and optical stimulation in the brain of freely moving rodents. This project aims at providing such a wireless optogenetic headstage system with user programmable functions, so it can address the dual nature of brain biopotentials, […]

MetaMixis, Inc., is a Canadain company undertaking a global effort dedicated to decreasing our reliance on petrochemicals by transitioning to engineered microbial processes or biocatalysts for the production of sustainable products. In the past few years MetaMixis has successfully developed a functional screen to recover metagenomic scaffolds sourced from various proprietary bacterial communities. They have […]

Osteoarthritis (OA) is a growing burden in an aging society. There are few proven treatments and hence disability contributes to poor quality of life and direct/indirect costs to society. Hyaluronic acids have been show to improve OA symptoms but usually the onset is delayed by weeks. Corticosteroid therapy in contrast has a quick onset of […]

The work proposed here is based on a novel and innovative approach which has not been addressed till today. We propose that developing a combined therapy to inhibit ErbBs and activate SSTRs, might be useful approach to control tumor progression and better hormonal therapy response in breast cancer. The outcome of the present study first, […]

The aim of this project is to develop a wrist based fall detection and activity monitoring device for older adults. This device will be used to reliably and automatically detect falls and alert the health care providers so that immediate help can be dispatched and made available to fallers. In addition to detecting falls, this […]