Analyzing the impact of the Lactobacillus rhamnosus R0011 secretome on intestinal epithelial cell and antigen-presenting cell interactions

Intestinal bacteria are now recognized as important for maintaining our health. Many questions remain about how these probiotic or health-promoting bacteria act to influence health, and how to use them to combat the numerous health problems associated with inflammation. The objectives of this research project are to determine how products made by one of these […]

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Early stage detection of ovarian cancer

Infections acquired through long-term catheter use are a major problem for nearly 20% of all patients. This project seeks to apply Econous Systems’ anti-fouling MEG-OH coating to biomedical plastic catheters to see if they prevent the 3 most common microbes: E. coli, C. Albicans and S. Aureus, f rom growing. This will initially involve in […]

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Development of an Auxetics Smart Textile for Applications in Healthcare Products

Smart wearable biomedical technology has a wide range of application in health monitoring during life activities or in traumatic situations. This technology can provide a practical and convenient solution for continuous health monitoring of elderlies, and patients suffering from different types of dementia like Alzheimer’s Disease. Additionally, the technology can facilitate trauma medicine by providing […]

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Translation of a Personalized Genetic Medicine Vector Production System

Mediphage Bioceuticals aims to leverage its DNA ministring platform for personalized genetic medicine. Mediphage Bioceuticals Inc. greatly appreciate Mitacs Accelerate program in providing support to (1) validate msDNA for gene delivery by carrying out a two-phase study, (2) develop and validate phage display libraries for the specific targeting and delivery to target host cells, and […]

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Identifying novel biomarkers and immune response profile correlating to clinical outcome in ovarian cancer patients treated with a T cell activating immune therapy

Cancer afflicts 1 in 8 people worldwide. Recent advancements in bench-to-bedside translational research has resulted in numerous effective treatments. However, a harsh reality still exists in that only ~20% of patients respond positively to treatment. Not all cancers are created equal, which has led to these clinical complexities undermining treatment options. It is our goal […]

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Discovery of Novel E3 Ligands for PROTAC Development

Protein degradation induced by PROTACs (PROteolysis TArgeting Chimeras) constitutes a novel modality of drug discovery, with advantages over the traditional approach. This approach is still at infancy and there is a lot to learn in this field. The trainees will work under academic supervisors at University of Toronto, who are experts in chemical tool development […]

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Bio-sourced reagents for the flotation of minerals in the mining industry

Many mineral ores are concentrated by froth flotation, a process that often uses toxic chemicals to selectively alter mineral surface properties. With increasing regulatory restrictions, the industry could face a dead end with no alternative reagents that are sufficiently efficient, low cost or environment friendly. It has been previously shown that peptides could selectively bind […]

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Identification and characterization of new antimicrobial chemical series

Antibiotic resistance represents a major health problem for society. With the expanded use of antibiotics, microorganisms have developed various mechanisms of resistance to overcome the effects of once highly effective agents. There is therefore an urgent need to identify new therapies to counteract resistant strains. The intern will design and identify new drugs that are […]

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Garment-based Neuroprosthesis, a non-invasive closed-loop neural extension for facilitating the human nervous system function

MYANT is a pioneer in the field of smart textiles, with the first connected e-textile ecosystem that can serve as a DSL cable connecting humans to their surroundings, others and themselves. This connected eco-system or platform is named SKIIN, representing a second skin, an intelligent interface, an augmentation of the human sensory and nervous system, […]

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Cell Preservation Techniques for Novel Probiotics

The purpose of this project is to develop encapsulation technologies that enable probiotic cells to maintain their dormancy and shelf stability within new food products. The project covers a discovery, validation, and scale-up phase. It addresses the use of various materials to produce capsules of probiotics and formulation of different products using them. The outcome […]

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