Although early clinical trials have been positive, peptide vaccine mechanism of action (how tolerance is induced) is unknown. The primary objective of these studies is to identify changes in gene expression and cytokine expression that are correlated with vaccine treatment. These changes could provide insight to mechanisms of action and may reveal potential genetic biomarkers […]

The somatic mutational processes that occur within human cancers generate novel, non-self proteins that have the potential to be detected by antibodies and therefore exploited therapeutically. Such antibodies can be generated through the stimulation of the immune system or through the synthetic generation of monoclonal antibodies (mAbs). The nascent ability to determine the complete transcriptomes […]

Risk Sciences International is currently completing a comprehensive risk assessment of the potential human health effects of manganese. This assessment involves a systematic review of the worlds’ literature on epidemiological and toxicological studies of manganese, following which an international expert panel has scored all of the adverse health outcomes identified through this review using a 12-point […]

The objective of this project is to test the feasibility of the membranes for membrane distillation (MD), developed recently by University of Ottawa researchers, to treat hog urine for the production of clean water in lab scale as well as with a demo unit. The MD process is eventually integrated as a part of the […]

Children living with NDDs are often dependent on their parents and healthcare providers. As these children reach adolescence and prepare to transition from the pediatric to the adult health care system many issues affecting their autonomy are currently not being addressed. In addition to feature articles, sidebar articles with multimedia components will further examine these […]

This project seeks to develop new methods for imaging oxidative and vascular function in the brain. The methods under development are based on widely available MRI hardware, which will make them feasible for use in future clinical drug trials, an application that is of interest to the partner organization CQDM. Before the approach is ready […]

In the prior Mitacs funding cluster, a clinical trial of opioid addiction was initiated and approved by both Health Canada and the ethics board of the Saint Joseph General Hospital. This research project expands upon that work. A smoking cravings reduction program using SmartStim transcranial direct current stimulation (tDCS) has been initiated by NorDocs, and […]

Photon Control Inc. is a Burnaby, British Columbia company that designs and manufactures a wide range of optical sensors & instruments to measure temperature, pressure, position, and flow in the semiconductor, oil and gas, power, life science, and manufacturing industries. The operating principle of many of their products is based on the optical response of […]

This project is designed to evaluate/test the viability of commercial live coccidial poultry vaccine. The efforts will be made to enumerate individual species within a mixture of several to many vaccine species. The current research revolves around viability-qPCR that may be able to simultaneously amplify and quantify parasites in a variety of samples and concentrations. […]

This project focuses on identifying models of care that improve patient outcomes while reducing costs on the system. The project, in partnership with a large pharmaceutical company, evaluates the economic burden of Alzheimer’s in Ontario, looking at the current utilization, costs and scope of home care services, the gaps in service, the reliance on alternative […]

A quantitative risk prediction model is to be constructed. We need to determine if the available data will fit an existing model and validate the results or if a new statistical model is required. Each case will be allocated into one of three categories (low, moderate and high risk). This stratification must have clinical validity […]

Chemotherapy drugs target and kill rapidly-dividing cells located closest to blood vessels, but do not penetrate deep into the tumor. Limited drug distribution in tumors is an important cause of drug resistance. A method to increase tumor drug delivery and combat resistance is the subject of this proposal. To counteract chemotherapy resistance, the use of […]