Toward an understanding of how YB-1 regulates drug resistance in glioblastoma multiforme through epigenetic regulation governed by BMI-1

Glioblastoma (GBM) is the most common and aggressive form of brain cancers and is the second most common cancer in children only behind leukemia. Conventional therapy consists primarily of surgery, radiation, and chemotherapy, and while these approaches have slightly improved the length of patient survival, there remains no cure for this disease. With the emerging […]

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A system dynamics model of the continuum of care for HIV

Operations Research — often referred to as the “Science of Better” — uses Mathematics to improve the efficiency of everything from the operation of airlines to hospitals. In collaboration with the BC Centre for Excellence in HIV/AIDS at St. Paul’s Hospital and Merck Frosst, this project will use Operations Research to improve the treatment and […]

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Continuity of care in children’s mental health: Finalizing a new measure

In Senator Kirby’s 2006 report, Out of the Shadows at Last, children’s mental health was labeled the “orphan’s orphan” of Canada’s health care system. For over two decades, the systems-of-care philosophy in children’s mental health has recognized the need to respond to a fragmented service system through greater integration and coordination. Continuity of care, which […]

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Osteoinductive, osteogenic and angioinductive potential of intramuscular injected genetically modified human umbilical cord perivascular cells

The loss of bone is a massive burden on the health care system and severely impacts the quality of life of several hundred million people. The need for alternative strategies to replace or regenerate bone tissue is overwhelming. We are proposing a completely new approach to the engineering of bone using a “cocktail” of genetically […]

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Implementation of a music-based walking program for clients of Parkinson Alberta Society

The proposed project seeks to build upon a recent pilot project that developed and evaluated a novel auditory reminder system that clients of Parkinson Alberta Society can employ to exercise large step walking outside of clinical settings. The pilot study highlighted a number of aspects requiring further investigation, both from clinical and research perspectives. Consequently, […]

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Assessment, piloting and establishment of a green health care revolving fund

The objectives of the research are to identify and quantify barriers to energy efficiency in Ontario Hospitals, and to identify methods to confront these barriers, focusing largely on the efficacy of revolving funds. Research findings will contribute to improving financing mechanisms for energy efficiency measures to greater mobilize their implementation in Ontario Hospitals.

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Web tools for intelligent real-time data analysis

Data analysis plays an important role in healthcare as it enables service providers to discover hidden knowledge in the data, allowing them make more informed decisions about patients’ health. The continuing increase in the amount of data and lack of skilled people, however, has made data analysis very challenging. This project aims at developing web-based […]

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Detection and quantification of organ toxicity biomarkers

In recent years, the interest given to disease biomarkers has boomed. Biotechnology and pharmaceutical companies are exploring ways to use biomarkers to speed up the drug development process, as well as to rapidly assess  diseases state, staging, progression and response to therapy. Multiple reaction monitoring (MRM) Mass Spectrometry (MS) has been shown to be well […]

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Attention and executive function training in children with Autism Spectrum Disorder

Many children with ASD experience significant difficulties with attention and executive function. This research will investigate the effects of a direct attention and executive function training intervention in children ages 6 to 12 with ASD (high functioning). Research has shown that it is possible to improve attention and executive functioning in children with various neuropathologies. […]

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