With the advent of antibiotic resistance, it has become increasingly important to develop alternatives to currently used antibiotics. In our laboratory, we have investigated the structure and function of a number of potentially interesting drug candidates. In the proposed project, we will design and develop a new generation of peptides derived from the two peptides […]

Surgeons routinely use electrocautery to remove unwanted tissue, seal off and cauterize small bleeding vessels in the tissue, or create a surgical incision. Cauterizing tissue, however, creates a smoke plume that contains potential carcinogens as a result of carbonization of proteins and fat. The (soft) tissues that are treated may also contain hazardous materials, e.g., […]

Infectious diseases remain the major cause of death and economic losses in animals/humans. One way to reduce this is by vaccination. Unique and sophisticated biotechnology-based approaches are needed to produce safe, cost-effective, and highly efficacious vaccines. Potential benefits of these vaccines could include the induction of long lived immunity, ability to immunize newborns and induction […]

The Xenotropic Murine Leukemia Related-Virus retrovirus (XMRV) is a gammaretrovirus of mouse origin that can infect humans and a broad range of animals. The virus was first identified in a subset and prostate cancer tumors and more recently in patients suffering from chronic fatigue syndrome (CFS). Studies estimate that between 3% and 10% of the […]

The Kothe research group studies the structure and function of small ribonucleoproteins which are involved in ribosome biogenesis, in particular in modification of ribosomal RNA, with the aim of better understanding how the cell assembles large RNAprotein complexes such as the ribosome. My basic research investigates the mechanism of the early stages in ribosome biogenesis […]

Brain to machine interface (BMI) is a research topic aiming to develop more direct interface between a human brain and a machine. The research is primarily motivated by desire to help humans who are in need of assistance or repair of theircognitive, sensory, or motor functions. In general, BMI is designed to be either invasive […]

There are two sets of literature estimating the cost of health interventions in different countries.However, actual program cost data are not available for all programs (whereas it is easier to generate estimates using the “ingredients approach”).  In this project, we will undertake a literature review to match actual program costs to those predicted by the […]

This is a major long-term and on-going project being undertaken by CanAssist. An organization dedicated to developing assistive technologies and services that will improve the quality of life and independence of those with disabilities (please see www.canassist.ca). One of our key research areas revolves around the development and provision of communication and control devices for […]

Our project consists of a combination of magnetic resonance imaging (MRI) and numerical simulations to model the blood flow dynamics in major cerebral arteries. In doing so, we hope to determine the shear stresses that are inflicted on the vessel walls of the brain, which should correlate with the vessel’s ability to dilate in response […]

Intensity-modulated radiation therapy (IMRT) is an advanced cancer treatment technology that uses beams of high energy x-rays to deliver radiation to a tumour.  In IMRT, radiation beams are divided into many small beamlets, whose intensities are individually adjusted in order to deliver a dose of radiation that conforms to the shape of the tumour.  The […]

Our laboratory is interested in developing imaging software and instrumentation that will allow us to measure the spatial dynamics of growing neuronal structures in a small, transparent, model organism called C. elegans. C. elegans is a small nematode (round worm) with a uniquely simple nervous system—it contains only 302 neurons and the connectivity between these […]

Providence Health Care has established a reputation as one of the leading centres for cardiology research and treatment in Canada. Medtronic of Canada is a major supplier of therapeutic cardiac equipment, technology and implantable devices, and works closely with Providence Healthcare to advance the science of cardiac treatment. Providence Health Care and Medtronic of Canada […]