The first objective of this project is to obtain the first high resolution impedance measurements of cardiac tissue. These measurements will be synchronized with electrocardiogram to determine quantitatively for the first time the changes of conductivity at different stages of the cardiac cycle. Since the heart is one of the most electrically-active areas inside human […]

This research project is directed towards the assessment and development of technologies that will complement the UV technologies provided by Trojan Technologies for water/wastewater treatment.  A novel liquid-solid circulating fluidized bed bioreactor (CFBBR) developed at the University of Western Ontario in collaboration with Trojan Technologies has generated a wide interest for commercial application for biological […]

Nowadays, most of cell biomechanics studies based on cell stretching have focused on small stretching magnitude, without the ability to visualize cell behavior and morphology during stretch. We therefor decided to build a cell stretcher/incubator providing the physiological conditions of cell culture (37°C, 5% CO2) while also allowing the application of a wide range of […]

Breast cancer tumors spread to the rest of the body through the sentinel lymph nodes (the first lymph node to receive lymphatic drainage from a tumor). The metastases of breast cancer can be controlled by the detection and removal of these nodes.  The surgical removal of the auxillary lymph nodes and perform biopsy tests is […]

A novel electrode was developed to measure pelvic  floor muscle activity in women. The novel design addresses several limitations of current technology, which uses large electrodes mounted on vaginal probes. These probes use inappropriate electrode configurations, have large electrodes susceptible to noise from nearby muscles (i.e. crosstalk), and noise from motion of the electrode relative […]

Immune thrombocytopenia (ITP) is a common blood disorder characterized by low platelet counts and an increased risk of bleeding. Many patients with ITP can be maintained with conventional therapies, but when an invasive procedure or surgery is planned, a short course of treatment is needed to rapidly increase platelet counts preoperatively so that dangerous bleeds […]

A simple and facile route for the construction of highly sensitive electrochemical enzyme biosensors has been proposed using carbon nanotube (CNT) complexes with a conducting poly(thiophene) polymer. Glucose oxidase was used as a model enzyme for the construction of the advanced biosensors. Glucose biosensors, exhibiting sensitivity higher than any biosensor based on CNTs and other […]

Breast cancer (BC) accounts for 15% of all cancer cases in Ontario, affecting 8,700 women in 2009.  Thus, there is a great need for the development of new anti-cancer agents and the identification of patients who are best suited for tailored treatment.  The drug metformin has emerged as a potential therapy for BC.  Metformin is […]

Individuals with speech problems face difficulties such as anxiety, poor socialization and poor literacy. Key to effective intervention and therapy is a better understanding of the brain activity associated with speech. Magnetoencephalography (MEG) is a new brain-imaging technology that, for the first time, allows researchers to monitor the fast-changing brain activity involved with speech. The […]

The goal of this project is to develop a prototype microfluidic device to rapidly determine whether a target protein is present in a sample. Applications of this device include genomic and proteomic research, pharmaceutical testing, and quality control for various industries, including food preparation. The prototype will make use of electrowetting on dielectric (EWOD) actuation, […]

We have developed a technology platform that allows us to obtain quantitative information regarding biomarkers much faster than currently possible, without the need to use expensive antibodies for detection. Our platform allows for simultaneous detection of many biomarkers at once. This reduces the time and the cost associated with biodiagnosis, and will directly contribute to […]

Quantitative steroid hormone measurements are a mainstay in the field of clinical endocrinology, due to their effects in myriad processes from maturation to hormone-sensitive cancers. Conventional steroid hormone testing protocols require a venopunture blood draw (~5 mL) followed by a time consuming immunoassay (~2 hr) each time a single  hormone is tested. In response to […]