Wide-Complex Tachyarrhythmia (WCT) is an abnormality in which the heart rate is elevated and QRS complex duration is increased. An electrocardiogram (ECG) is a simple and quick test used to review heart functioning, so ECG images can be used to determine whether a patient is having an abnormal heart rhythm such as WCT. A WCT […]

Fungal pathogens cause life-threatening invasive infections in humans. Despite all available treatments, mortality rates remain unacceptably high, on par with deaths caused by infectious diseases such as tuberculosis and malaria. Alarmingly, the emergence of drug-resistant fungi is reducing already limited treatment options. To address needs for new antifungal medications, Amplyx Pharmaceuticals has developed fosmanogepix, a […]

Anxiety disorders and chronic stress represent major healthcare and economic burdens worldwide. Approximately 75% of Canadians who use health services for a mental illness present with anxiety disorders which may affect up to 10% of the population in terms of lifetime occurrence. Despite the large prevalence of anxiety-related disorders in Canada, there are currently a […]

In this project, an oncolytic virus will be generated that combines the safety profile of vaccinia virus, with the immunostimulatory power of RNA-vaccines. Currently, the RNA-genomes of Alphaviruses are successfully used to encode proteins to be vaccinated against. Their special genome organization and makeup allow them to self-amplify within a cell. This replication in turn […]

One rapidly evolving area of cancer therapeutics is immunotherapy, which aims to drive a cancer-targeted immune response in tumors. Replicating virus-based therapeutics are a novel cutting-edge immunotherapy that have shown promise clinically. Turnstone Biologics has developed a novel cancer-killing virus with the capacity to deliver multiple payloads to further enhance the virus’ anti-cancer effects in […]

Oncolytic viruses (OVs) are promising biotherapeutics that selectively infect and kill cancer cells. The efficacy of oncolytic viral therapy depends on the virus’s efficient replication and dissemination within tumors. However, tumors often develop a dense extracellular matrix (ECM) surrounding their cells that provides resistance against many forms of cancer therapies including OVs. To overcome this […]

Through engineering and selection strategies, we have created novel cancer-killing oncolytic viruses (OVs) that are selective for tumours but are unable to grow in normal tissues. A critical component of the therapeutic activity of this class of therapeutics is the induction of an anti-tumour immune response, which can be suppressed in many tumours. One strategy […]

Many aspects of healthcare are time consuming and error prone. Recently there has been great progress in using artificial intelligence to solve a number of problems. One of the best examples of this is image labelling using a type of neural network approach called deep learning. Recent research has shown that deep learning approaches can […]

This program will cement Canada’s leadership in global Very Long Baseline Interferometry (VLBI), a key technology in radio astronomy and geodesy. In partnership with Thoth Technology Inc., our team of leading radio astronomers will (i) develop new capabilities to compress, transport, and process large amounts of data between geographically distinct locations to enable real-time VLBI, […]

We are proposing to use a rapid, safe and green electroplating process to adhere antimicrobial phosphonate quaternary ammonium materials onto receptive metal surfaces. Pathogenic infections are responsible for approximately 60% of all hospital acquired infections. In order to help stop the spread, high contact surfaces such as bed rails in hospitals, door knobs etc. require […]

Durham Region is committed to responding to the climate emergency by embedding climate change considerations across all elements of Regional business. This research will involve an examination of the Region’s entire waste management system and develop a full life cycle analysis model for GHG emissions which can be used to identify opportunities and support strategies […]

Our space-based radio-frequency communication is suffering from the use of simple phase shifters. Its bandwidth capability is limited, ultimately reducing the satellite’s capacity and the system’s service availability. Most electronic beamforming implementations are bulky, frequency dependent and they consume a significant amount of power. To replace those electronic components, structures which guide light on microchips […]