A Knowledge Management System for Knowledge-Intensive SMEs

Knowledge-intensive enterprises (KIE) play an important role in the knowledge-based economy (OECD, 2007). Knowledge-intensive enterprises can be loosely and preliminary defined as organizations that offer to the market the use of fairly sophisticated knowledge or knowledge-based products and services (Doloreux & Shearmur, 2011). Knowledge management is important for both large enterprises and small and medium-size […]

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Classification automatique par ordinateur d’images de diatom?es (algues)

Les diatom?es sont des microalgues que l’on retrouve dans les cours d’eau (aussi dans les lacs et les oc?ans). Il a ?t? d?montr? (travaux d’un collaborateur en sc. de l’environnement) que la distribution des esp?ces dans un cours d’eau est un bio-indicateur de l’?tat de celui-ci (pollution, etc.). Les diatom?es sont distribu?es parmi des centaines […]

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omics’-based platform and synthetic biology for the elucidation, characterization and production of plant natural products.

Alkaloids constitute a diverse class of natural products and due to their potent biological activity, many are commercially exploited. Most alkaloids are derived from amino acids and characterized by a nitrogen atom in a heterocyclic ring. Recently, the alkaloids produced by Amaryllidaceae plants (e.g. Narcissus (daffodils) and Galanthus (snowdrop)) have been attracting increasing interest due […]

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Energy management of multi fuel cell vehicles

Power train electrification is currently one of the best solutions in order to design cleaner vehicles. Nevertheless, the internal combustion engine is still essential to ensure high vehicle autonomy (over 500 km) and fast re-fuel (under 5 minutes). To obtain a commercially-competitive electric vehicle, important progress must still be realized concerning the energy storage and […]

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Cell survival and cell death regulation in gynecological cancers.

BACKGROUND & RATIONALE Endometrial cancer (EC) is the leading type of female genital cancer in the Western world and ranks fourth among the most common cancers in women. Patients with tumour confined to the uterus are treated with surgery and radiotherapy; however, more than 25% of patients diagnosed with endometrial carcinoma have an invasive primary […]

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Biomedical applications of HIV-1 restriction factors

Project: genome editing of restriction factors to confer resistance to HIV-1. The human versions of restriction factors APOBEC3G and TRIM5alpha are unable to efficiently target HIV-1, because of 1) an inability of human TRIM5alpha to physically bind its target, the capsid protein of HIV-1; and 2) the degradation of human TRIM5alpha by the specialized HIV-1 […]

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The role of PML in anti-retroviral innate immunity (New)

The PML (promyelocytic leukemia) protein, also called TRIM19, is an interferon-induced antiviral factor. It directs the formation of nuclear bodies that are rich in heavily SUMOylated proteins and are often associated with viral replication sites. PML can “silence” (prevent the expression of) several viruses, including retroviruses, and its action is often counteracted by viral proteins. […]

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Electrospun nanofibers for adsorption of pollutants from wastewaters

The overall objective of our research project is to develop a technology that will help many industries and more specifically the pulp and paper industry to reduce their fresh water consumption and by the same way their effluent discharge. To achieve this, it is mandatory to remove several contaminants from process waters because the reduction […]

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Ontario Power Grid Modelling for Incorporation of Renewable Energy Sources

The research project is to model the Ontario power grid and its constituent zones in order to determine the best locations for wind turbine farms and distributed power sources. A basic model of the Niagara Zone has been constructed, involving the location of the power generation stations, major demand centres, and transmission systems. The model […]

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Role of Nlrs in neurodegenerative diseases (New)

Nlrx1, belongs to NLR family of intracellular sensors that regulate mayor cellular pathway including cell death and inflammation. Previous research implicated Nlrx1 in regulation of autophagy and reactive oxygen species production during viral infection. In addition most recent publication implicated Nlrx1 in regulation of the cell death in fibroblasts cultures. Our preliminary data show that […]

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