Epilepsy is a complex disorder, affecting roughly 1% of the global population. Treatments are available, but many patients (~1/3) are resistant to existing therapies, which have become economically challenging. In this project we will investigate a new class of anti-epileptic drugs that target neuronal voltage-gated Kv7 potassium channels. The intern will characterize the mechanism of […]

Xenon has developed isoform selective blockers of the sodium channels that are expressed in CNS neurons with the intent of developing them for therapeutic use, especially epilepsy. The primary goal of this research project is to determine the activity of compounds on CNS neurons. Until now, all characterization has been done with heterologously expressed channels. […]

Voltage-gated sodium channels are key contributors to excitability in living organisms; hence, modulation of these channels through mutations and/or environmental triggers can often lead to serious disorders. Having an enriched understanding of the sodium channel electrophysiology may result in uncovering potential therapeutic targets. The general aims of our research include studying the effects of various […]

This project aims to validate and optimize drugs to treat heart rhythm disorders. The heart is a complex organ that uses tiny electrical signals to maintain a healthy rhythm. When these electrical signals are disturbed, it can change the regular rhythm, which can result in life-threatening consequences such as sudden cardiac death. Here, I will […]