While we enjoy the modern convenience brought by a multitude of man-made organic chemicals, such as surfactants and flame retardants, the exposure to these compounds, some of which are bio-accumulative, persistent and even toxic, may endanger our health. Humans are exposed to chemicals in consumer products during both product use in the indoor environment (near-field […]

The Ontario government provides healthcare funding to fourteen Local Health Integration Networks (LHINs) across Ontario. LHINs in turn are responsible for structuring health care delivery and allocating funds to best meet the needs of the population in the region. However, there are limited tools available to help LHINs evaluate the system-wide implications of proposed policy […]

Li-ion batteries (LIBs) are currently the most important power source for a wide variety of applications such as cell phones, laptops, computers and other portable electronics. They are also considered as very promising storage/power systems for future electric/hybrid-electric powered transportation. Although clever cell design and improvements in cell subcomponents can bear potential for volume and […]

Geomechanica Inc. develops simulation software (Irazu) for rock engineering applications. This numerical software has been used in several peer-reviewed research publications in the rock mechanics field. A key challenge in the numerical modelling of rock masses is the selection of appropriate input parameters. The objective of this work is to develop a solution to streamline […]

Proteins can exist in two forms: left-handed (L) or right-handed (D); however, for indeterminate reasons life on this planet only uses the L-form. When studied in more detail, both protein forms possess identical physiochemical and biological properties. Yet, D-proteins show minimal proteolytic degradation and fail to elicit immune responses in animals, due to their unnatural […]

Signaling through the Eph family of cell surface receptors is crucial for embryonic development and the maintenance of adult tissues. Given the central role of the 14 Eph receptors in controlling cell fate, it is not surprising that they also play a central role in oncogenesis and other pathological conditions. However, the signaling mechanisms of […]

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect […]

Air pollution is a major concern in urban centers because not only does affect vulnerable populations, but also impacts the quality of life for urban dwellers. With the new implementation of the Air Quality Health Index (AQHI) by the Ontario Ministry of the Environment and Climate Change to replace the existing Ontario Air Quality Index […]

Membrane proteins such as ion channels, transporters or G-protein coupled receptors (GPCRs) are excellent but difficult drug targets involved in a large number of life-threatening diseases and conditions. These proteins, over-expressed and essential for disease onset and progression, are naturally targeted by toxins from venomous organisms. During evolution, these toxins have been optimized to efficiently […]

The NSERC Strategic Network for Smart Applications on Virtual Infrastructures is a five-year partnership between Canadian industry, universities, researchers, research and education (R&E) networks, and high performance computing centres to investigate the design of future application platforms that will deliver software applications of greater capability and intelligence. These application platforms will be supported by an […]

Helicopter training simulators are an important part of improving the safety of both civil and military helicopter operations. The most important part of helicopter training simulators is the model of the helicopter dynamics since it drives all the other simulator subsystems. This project aims to provide CAE with a more automated and accurate method for […]

The objective of this research is twofold: to improve existing risk management framework to assess interest rate shocks, and to develop a new risk factor model to create an equity risk score system to help guide investment decisions. The first part of this research project involves the development of an equity risk score system to […]