The continuum of HIV care is highly complex. It includes prevention, testing, patient care, treatment, and support services. This project will help Providence Health Care utilise its limited resources to provide the best treatment and care for people living with HIV in Vancouver. Care for HIV patients includes antiretroviral therapy, treatment of co-morbidities, monitoring clinical […]

Membrane proteins such as ion channels, transporters or G-protein coupled receptors (GPCRs) are excellent but difficult drug targets involved in a large number of life-threatening diseases and conditions. These proteins, over-expressed and essential for disease onset and progression, are naturally targeted by toxins from venomous organisms. During evolution, these toxins have been optimized to efficiently […]

Detecting subtle chemical and physical changes occurring at the early stages of chronic disease and many other infectious diseases caused by harmful bacteria is still a challenge, as ultra-sensitive sensors with large signal-to-noise-ratio are required to detect them. We recently explored new ways to enhance the sensitivity of magnetic nano-sensors and theoretically demonstrated that under […]

Customized image sensors will be designed by EnviroSen specifically for advanced microscopes used in biomedical imaging. The goal is to develop image sensors with improved efficiency, image resolution and speed compared to existing technologies for novel microscopes for fluorescence lifetime imaging. The McMaster Biophotonics group has recently developed a novel microscope that is capable of […]

Air pollution is a major concern in urban centers because not only does affect vulnerable populations, but also impacts the quality of life for urban dwellers. With the new implementation of the Air Quality Health Index (AQHI) by the Ontario Ministry of the Environment and Climate Change to replace the existing Ontario Air Quality Index […]

Extensive research has been conducted for the computational analysis of mass spectrometry based proteomics data, however most of the traditional computational approaches take the assumption that the acquired spectra are generated from the fragmentation of a single precursor and the peptide is simply a linear sequence of amino acid residues. This ubiquitous assumption is impeding […]

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect […]

Signaling through the Eph family of cell surface receptors is crucial for embryonic development and the maintenance of adult tissues. Given the central role of the 14 Eph receptors in controlling cell fate, it is not surprising that they also play a central role in oncogenesis and other pathological conditions. However, the signaling mechanisms of […]

Intrusion detection has attracted the attention of many researchers in identifying the ever-increasing issue of intrusive activities. In particular, anomaly detection has been the main focus of many researchers due to its potential in detecting novel attacks. However, its adoption to real-world applications has been hampered due to system complexity as these systems require a […]

The way a vaccine performs after injection is not completely understood and not all vaccines behave in the same way. To make a vaccine we must understand what is important or critical to make it work. For example a vaccine may have specific features such as its size or shape that are critical to the […]

Proteins can exist in two forms: left-handed (L) or right-handed (D); however, for indeterminate reasons life on this planet only uses the L-form. When studied in more detail, both protein forms possess identical physiochemical and biological properties. Yet, D-proteins show minimal proteolytic degradation and fail to elicit immune responses in animals, due to their unnatural […]

Often, a single employment notice may receive hundreds of applications. Manual inspection of applications is extremely time-consuming, and may be approximated by a computer program. Such a program would automatically extract a number of features from each application. For example, relevant work experience, skills, and qualifications might represent appropriate features. After extracting these features, the […]