Ce projet vise à élucider davantage le mode d’action de certains produits élaborés par ProMetic BioSciences inc. sur certaines cellules myéloïdes humaines en relation avec une réponse cellulaire impliquée dans un nombre grandissant de maladies humaines. Il s’agit d’un stress du réticulum endoplasmique (RE), un organite cellulaire impliqué dans la synthèse des protéines. Cette dernière […]

The liver is the largest solid organ in the body and is critical for metabolic and immune functions, however huge gaps still exist in our basic knowledge of the human liver. Due to challenges in obtaining human liver tissue and the fragility of liver specimens, little is known about the cells that make up the […]

Enhancing tissue homeostasis and immune tolerance mechanisms is pivotal for the development of new therapeutic approaches for transplantation and autoimmunity. This proposal is focused on harnessing newly discovered types of lymphocytes that regulates immune responses in cell-based immunotherapies. We are developing methods to isolate and expand these newly identified regulatory lymphocytes and are assessing their […]

This project will pair together a academic Canadian research group with a pharmaceutical company who have developed a novel therapeutic (ALY688) to the stage that it will soon begin phase 1 clinical trials for the treatment of metabolic disease, such as diabetes. Since the success, and safety, of clinical trials requires accurate dosing of the […]

IMV has developed a novel depot-based vaccine platform that can be used with a variety of antigens and adjuvants, which can exhibit rapid and enhanced immune responses following a single dosage. This project will use cell tracking via molecular MRI to explore the immune cell migration in real time in an animal model of cancer, […]

Blue-O Technology Inc has identified five proprietary samples that may have antiviral activity, either in prevention or treatment of viral infections. The intern will determine the activity range and toxicity of each proprietary samples in mammalian cells and a mouse model. Once this has been determined, each proprietary sample will be tested for its ability […]

The proposed project is to develop a bioaerosol sampler which will have minimal impact on the infectivity of captured viruses. Airborne viruses are subjected to environmental conditions which could affect their potential of infectivity as well as their capacity to resist the shearing forces and desiccating conditions during sampling procedures with standard sampling apparatuses. This […]

NovoBind, in partnership with Dr. Finlay will determined the efficacy of a number of novel molecules capable of neutralizing various pathogens including enterobacteriaceae. These studies will demonstrate the mechanism of action and viability of a new approach to pathogen control. These key assays which characterize the efficacy of our technology in an in-vitro setting will guide their […]

Cancer is one of the leading causes of death worldwide with approximately 8 million deaths in 2010. Most cancer treatments lack specificity and affect the whole body, with toxic effects on both cancerous and normal cells. Although new therapies are emerging, targeting cancer cells is a challenge because of the lack of specific markers on […]

We will assess the quality and suitability of blood and blood-derived products using a fast and economical approach that combines measurements of molecules in the blood product identified by their weight and computational approaches to make sense of all the data generated. Normal blood products have thousands of small molecules in common. By monitoring a […]

Significant advances in technologies related to antibody discovery and development have allowed therapeutic antibodies to become the fastest growing class of biopharmaceuticals over the last 20 years. Northern Biologics is a biotechnology company that seeks to develop therapeutic antibodies for the treatment of cancer and fibrosis. Together with Dr. Jean-Philippe Julien at SickKids (University of […]