Design and validation of a novel peptide immunotherapeutic for the treatment of dog allergies – Year two

Adiga Life Sciences Inc. developed a novel immunotherapeutic platform in which small components (peptides) of allergen proteins are identified and administered in a regimen that causes immune cells to become non-responsive towards the allergens. In a phase II clinical trial, the cat allergy treatment developed by Adiga using this platform reduced allergic symptoms in allergic […]

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Diagnostic Screening for Conscious Awareness in Brain Injury and Disease: Developing the Visual Component

Presently medical personnel do not have adequate tools to assess disorders of conscious awareness after severe brain injury if the patients have difficulty speaking & moving. These people are frequently deemed unresponsive when they may be “in there” but unable to respond. Our research team has developed a rapidly administerable, portable system that measures brain […]

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Imaging brain fuel metabolism in Alzheimer’s disease

Alzheimer’s disease (AD) is a major challenge for the individual affected, society at large and there only modest effective drug treatment. We believe that a central problem in AD is the deteriorating fuel supply to the brain (mostly the sugar, glucose) and this impairment appears long before the onset of memory and cognitive problems emerge. […]

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An Evaluation of the Sam Sullivan Disability Foundation

The Sam Sullivan Disability Foundation (SSDF) is a fundraising entity supporting six not-for-profit societies that provide opportunities for social engagement for people with disabilities. The six societies provide design opportunities for accessibility solutions; connect people with employment, training, and social opportunities in the community; and make sailing, music, gardening, and the great outdoors more accessible. […]

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Assessment of Tissue Viability in the Lower Extremity of Diabetic Patients

In Canada, people with diabetes are 20x more likely to have an amputation of their lower limb than the general population. Having a diabetic foot ulcer (DFU) increases the risk of amputation by 50%. Early assessment and treatment of a patient’s DFU can prevent amputation, but patients with diabetes often lose sensation in their limbs, […]

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Microbiota characterization and modulation through the use of generated probiotic strains to combat colitis-associated colon cancer

A higher incidence of colon cancer is reported in populations consuming high amounts of red meat, as well as in patients with inflammatory bowel disease, where gut bacteria participate in the development of inflammation. We found that dietary supplementation with heme, an element found at high levels in blood, is detrimental to gut health and […]

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In-silico identification of driver alterations and prediction of therapeutics targeting actionable drivers in prostate cancer

Cancer arises as a result of deleterious aberrations in the DNA, RNA and proteins of cells. The accumulation of genetic abnormalities, over lifetime, perturbs critical functions of cells, which may ultimately give rise to tumor. However, vast majority of these aberrations are not essential and only small fractions, known as “driver” genes, are critical for […]

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Deciphering the role of the tumor suppressor p53 in regulating treatment-induced ovarian cancer cell fate decisions in vivo

As the most lethal gynaecological cancer, ovarian cancers not only threaten lives of many women worldwide, but health side effects also burdens the life of millions patients following treatments. Novel therapeutic methods aiming at increasing the long-term survival of patients and decreasing health side effects associated with treatment is critical. We have already found that […]

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