Canada produces about 9 billion eggs per year; of these, about 27% are processed at egg breaking plants that yield low value eggshell (ES) and eggshell membrane (ESM) waste as a byproduct. The objective of this project is to develop processes to isolate high value products from ESM waste including HA, collagens, other proteins and […]

Pulmonary arterial hypertension (PAH) is a progressive condition characterized by the chronic elevation of pulmonary artery (PA) pressure leading to failure of the heart. In spite of recent advances in approved therapies, PAH remains a serious disease with significant mortality. In contrast to the earlier belief that contraction of pulmonary vessels played a key role […]

Upper limb physical impairments complicate the patient’s everyday tasks and possibly his ability to be independent with functional activities. Robotics technology is a promising approach for the rehabilitation of upper limb physical impairment. Indeed, the use of robotic systems helps therapists apply flexible, scheduled, and consistent therapy for long period of time, and has great […]

Osteogenesis imperfecta (OI) is a heritable disorder that causes bone fractures. The drugs that are used at present help to decrease the number of fractures by about half, but most people with OI have many fractures despite receiving currently available treatments. Mesentech Inc has developed a new drug that has shown a strong effect on […]

Emphysema, a lung disease that millions of Canadians currently suffer from, has few safe and non-invasive options available. One of the features of emphysema is the lack of proper blood flow in the diseased lungs and this results in poor gas exchange. IKOMED Technologies Inc. has been developing a new technology that has the potential […]

The number of Canadians living with diabetes is at an all-time high as are the consequential healthcare costs. A scalable solution to this public health crisis is needed. The aim of this research project is to evaluate Transform, a digital health program created by Blue Mesa Health. The program is designed to prevent diabetes by […]

Inversago and CR-CHUM will collaborate to evaluate new generation Cannabinoid-1 receptor (CB1) blockers for the treatment and/or prevention of type-1 and type-2 diabetes. Previous generations of CB1 blockers have shown their promise in treating several features of the metabolic syndrome, including obesity, type-2 diabetes and liver diseases. However, they were plagued with important psychiatric adverse […]

The net 5-year survival rate for patients suffering from liver cancer is less then 20 percent and the number of cases is rapidly increasing in Canada. Unfortunately, currently available oral chemotherapies can only extend median survival by 3 – 4 months making the development of new and effective drug treatments critical. The proposed study aims […]

In order for the brain to function well, it is important that blood vessels within the brain are healthy. In a healthy brain, these blood vessels can become larger and smaller when necessary, but this is no longer possible after epileptic seizures. An important group of compounds that regulate the size of blood vessels is […]

The most important structure in the human brain is the cerebral cortex. It makes it possible to perceive our visual environment and sounds, to perform motoric actions such as grasping an object, to speak, to understand speech, etc. The cerebral cortex is a 2-5 mm thick sheet, embedded in the skull. Analysis of MRI data […]

Chronic obstructive pulmonary disease (COPD) is an important global health problem afflicting 384 million people and causing 3 million deaths worldwide each year. Currently, there are no effective therapies for COPD patients. In this proposal, we are developing a novel technology that will both monitor the severity of disease in COPD patients, and allow researchers […]

Contact lens discomfort is one of the primary reasons that cause people to stop wearing them. The discomfort may be due to the buildup of tear film components on the lenses during lens wear. The purpose of this project is to understand where most of the tear film components are depositing on the lens, such […]