Proof of Principle Application for Biosensors in Animal Models

NXTSens has developed an implantable continuous monitoring, stand-alone and potentially mass-producible microsensor for accurate monitoring of tissue pressure and temperature in damaged limb muscles to better diagnose ACS. The proposed research will involve several sub-projects that include: i) develop appropriate surgical models for the accurate and reproducible placement of the microsensors in rodent compartments; ii) […]

Read More
Understanding the cellular mechanisms sustaining functional capacity improvement with prehabilitation in colorectal cancer patients

Cancer is associated with weight loss, decreased muscle strength and inflammation. This has a tremendous impact on daily activity, autonomy and quality of life, involving both patients and care-givers. I previously worked on a preoperative intervention called ‘pre-habilitation’, a personalized exercise and nutritional supplementation delivered before surgery. The main idea is to prevent postoperative complications […]

Read More
Ultra-low power wireless sensor node design for health monitoring use cases

In this project we address the problem of power consumption for wireless sensor nodes. This is where among different components of a sensor, RF transceivers consume a significant amount of power e.g. approximately 80%. Hence the main objective is this project is to tackle the power consumption problem at the RF transmitter, where we aim […]

Read More
Expression of muscarinic receptors in neurogenic detrusor overactive (NDO) bladders of spinal cord transected (SCT) rats after preventive treatment with anticholinergic me

Following the study of spinal cord transected (SCT) rat models being treated by fesoterodine fumarate (antimuscarinic drug) to prevent neurogenic detrusor overactivity, bladders of all 30 animals were conserved. It was observed that an early fesoterodine fumarate administration at the time of transection modulates bladder overactivity. However, the exact mechanism of action is not known […]

Read More
Evaluation of interventions for improving maternal, newborn, and child health outcomes: Systematic literature reviews and network meta-analyses

Poor nutrition, sanitation and hygiene, and infectious diseases during pregnancy and early childhood can lead to poor growth and development that can be everlasting negative effects on the child. A large number of clinical trials have been conducted, but as many interventions have not been compared against each other, it is unclear what interventions are […]

Read More
TREATING INFLAMMATORY BOWEL DISEASES THROUGH BLOCKING P2Y6 RECEPTOR

Extracellular nucleotides can favour inflammatory diseases via the activation of P2 receptors. The proinflammatory P2Y6 is the dominant nucleotide receptor in human and murine intestinal epithelial cells (IEC) and its expression increases during inflammation. Interestingly, we found that the blockade of P2Y6 totally prevented inflammation in the murine DSS model. This project will show whether and […]

Read More
An investigation into the psychometric properties of patient-oriented measures in frailty and dementia – Year Two

Patient centred measures can facilitate better health outcome$ by focusing on symptoms considered important to the patient. Goal attainment scaling (GAS), a system of goal setting which places the emphasis on the symptoms of individual patients, has been utftlzed In dementia research. However, It Ia unclear whether GAS Is atilt sensitive to symptom changes (responsiveness) […]

Read More
Factors Related to Braille Acquisition Among Adult and Senior Learners: Establishing Evidence-Based Practice

The ability to read carries important implications for overall self-esteem and independence, as reading is necessary to perform many daily tasks (making grocery lists, reading prescriptions, following recipes). Rehabilitation professionals provide training and support to adults and seniors who are born with visual impairments or who acquire it later in life due to age-related conditions. […]

Read More