The major focus of this proposal is to perform preclinical studies to support clinical development of a novel inhibitor for treatment of different caners such as breast, lung, colorectal and kidney. We have recently developed a novel therapeutic protein that selectively inhibits multiple pathways for treatment of advanced prostate cancer. A goal of this project […]

The bedsore or pressure ulcer is a serious health problem that affects many individuals with spinal cord injury (SCI). These ulcers mostly develop on skin that covers bony prominences of the body, such as the hips and tailbone. Pressure ulcers are often very difficult to treat and not only negatively affect patients’ health, but also […]

Pressure ulcers are among the top five leading causes of re-hospitalization in patients with spinal cord injuries (SCI). Unfortunately, current conventional prevention and treatment methods have neither decreased the prevalence of these ulcers nor significantly improved their outcomes. To address this difficulty, here, we will test the efficacy of our new liquid skin substitute to […]

Heart failure (HF) is one of the leading causes of hospitalization and rehospitalization in older adults, yet the majority of HF-related readmissions are preventable if patients can manage their treatment at home. One method to help patients who require extra assistance in following their treatment is through mHealth applications. However, these applications are not usable […]

As our population ages, the burden of dementia is growing. Alzheimer’s disease (AD) is the most common cause of dementia; currently we do not have any disease-modifying treatments for AD. There is motivation to better understand the mechanisms of AD development and expression to control the burden of disease. Frailty is related to neuropathological features […]

There are many examples of video games that have successfully used cutscenes and in-game dialogue to deliver engaging stories. But there is one market segment where story hasn?t been a focus, namely casual games. Given such games are primarily intended for a broader audience, have a much smaller budget, and typically focus on short experiences […]

Chemotherapy is currently the most effective approach for treatment of advanced cancer. However, chemotherapeutics do not differentiate between malignant and normal cells, and lead to serious side effects. Recent findings indicate that a substantial proportion of cancers, as distinct from normal tissue, are deficient in an enzyme called methylthioadenosine phosphorylase (MTAP). This provides a unique […]

Insulin is a hormone released from the pancreas, which controls the level of glucose in blood. Diabetes is a disease characterized by a lack of insulin production or impaired insulin action. Here, we propose the development of a novel system based exclusively on the measurement of insulin using capturing molecules with high affinity to insulin. […]

Abdominal pain is a debilitating symptom for many patients with inflammatory bowel disease (IBD). An endogenous opioid system emerges in the intestinal tissues during chronic inflammation that acts to dampen such pain and could prevent the need for strong opiate drugs like morphine that can cause serious side effects. However, we have discovered that psychological […]

Nearly 2 % of school-aged children face difficulty in understanding speech in the presence of background noise. These children are often referred to audiology clinics for a central auditory processing (CAP) assessment. The purpose of the referral is to rule out an auditory processing disorder (APD). The American Speech-Language-Hearing Association recommends to include electrophysiological measures […]

In this collaborative project with Muscular Dystrophy Canada (MDC), we will design and run choir singing and dancing programs for people with neuromuscular conditions, in order to study whether it improves their quality of life and their ability to breathe. Both singing and dancing have been shown to have significant medical and quality of life […]

Organisational change is part of life for sports teams, however, research suggests that despite how often change initiatives occur, the success rate for organisations achieving their desired outcomes is less than 30%. The aim of the study is to investigate how top level sports organisations manage change and to compare the different approaches adopted by […]