The role of integrins in stretch-induced activation of TGF-?1 and pulmonary fibrosis

Fibroproliferative disorders are the leading cause of morbidity and mortality worldwide. A large group of interstitial lung diseases (ILD) can cause progressive scarring of lung tissues, affecting the ability to breathe. Idiopathic Pulmonary Fibrosis (IPF) is one of the major forms of ILD and is characterized by a progressive decline in lung function. Although the […]

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Physiological assessment of cochlear and auditory nerve integrity in children suspected of auditory processing disorder

The American Speech-Language-Hearing Association (ASHA) recommends to include electrophysiological measures in their auditory processing disorder (APD) assessment battery. But few audiologist include electrophysiological assessment due to lack of evidence. There is strong evidence of auditory brainstem abnormality in these children. However, very less is understood about stimulus processing within the cochlea, auditory brainstem coding in […]

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Oncolytic HSV-1 (oHSV-1) for treatment of prostate cancer

This project is to use genetic engineered “cold-sore” virus to treat prostate cancer. The virus is engineered to reduce its toxicity to normal tissues but can specifically attack and kill tumour cells. Meanwhile, the virus releases a group of anti-tumour immune stimulating factors to activate immune system to eliminate prostate tumour. This project will use […]

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Perpetual Nomads: an exploration of indigenous narratives and imagery through contemporary and experimental mediums

The goal of the Perpetual Nomads project is to make illustration depicting many indigenous and environmental issues through traditional art media and digital media. The team will be exploring the viability of creating Mixed Reality interactive experiences to increase the awareness, empathy, egalitarianism and environmental concern in users through these illustrated narratives. Since people use […]

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The design and evaluation of a wearable technology as an effective tool for promoting early childhood physical literacy development

With childhood obesity and inactivity on the rise at an alarming rate, many government, education, and health agencies are promoting the development of physical literacy to combat this “epidemic.” The concept of childhood physical literacy refers to the development of fundamental movement skills that permit a child to move confidently and with control, in a […]

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Characterization of Naturally-Occurring Neuropathic Pain in Dogs

Clinical experience demonstrates that canine patients commonly suffer from neuropathic pain and little is known to address this issue. Our study aims to investigate different tools for the diagnosis and treatment of neuropathic pain. Forty dogs with naturally-occurring neuropathic pain will be included in a prospective, randomized, masked clinical trial using appropriate inclusion and exclusion […]

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Novel Cell-surface Engineering Methods to Increase Immune-tolerance of Allogenic Cell Transplantation

Blood transfusion is required for surgery, for the treatment of traumatic accidents and for patients with disorders that require lifelong transfusion therapy. However, when patients receive “mismatched” blood transfusion, their immune system will attack and destroy red blood cells with surface sugars and proteins that differ from their own. This results in massive immune responses […]

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Effect of Different Carbohydrate Sources on Starch Fractions and Glycemic Index in Commercial Extruded Dog Diets

Obesity and diabetes are leading nutrition-related disorders among pets in North America and have significant impacts on animal morbidity and mortality. The glycemic index, a measure of post-prandial blood glucose response, has been shown in humans to significantly impact glucose control, insulin sensitivity, weight management, and chronic disease risk. In pets, the effects of carbohydrates […]

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A Computational Modelling Framework for Evaluation of Pandemic Vaccine Strategies

Medicago, a clinical-stage biopharmaceutical company, has the potential to rapidly develop a vaccine in response to a newly sequenced influenza strain, allowing for large-scale vaccination of the population very early during a pandemic. The company would like to know how many doses of vaccine is required and what distribution strategies should be used to maximize […]

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