TRUSTSPHERE is a secure digital connection allowing patients to securely donate data and for researchers to ethically access patient’s data. The TRUSTSPHERE Consortium will create a links from mobile devices to providers, patients, and their families which will be tested and implemented to help with adopting this tool for management of children with Type 1 […]

Obstructive sleep apnea (OSA) is a common disease characterized by recurrent collapse of the airway during sleep leading to sleep fragmentation and daytime sleepiness. OSA is usually diagnosed based on an overnight sleep study (polysomnogram) which collects detailed physiologic information over the night. OSA patients are also at increased risk of cardiovascular disease such as […]

Disengagement is not a “steady state” rather it is better conceptualized on a continuum with engagement in some areas as well as disengagement in others (Christenson and Thurlow 2004). The proposed research will explore how issues of access and equity factor into student engagement within the university setting. In particular, this research explicitly examines “push” […]

The overall objective of the proposed project is to construct a simulation model that will estimate production impact of disruption in swine marketing in Ontario, and propose mitigation strategies that could minimize impact of such disruption on swine populations and swine producers. Such disruption could occur due to various reasons such as outbreak of human […]

This study will validate the accuracy of a new artificial intelligence (AI) powered application, which has been developed to track communication and cognition during the babbling stages of development in the first year of life. Once validated, this app will be an asset to both parents and clinicians. It will be used by parents and […]

In the present project, we aim to contribute to the investigation of the potential use of botulinum toxin (BoNT-A) injections in the brain for the treatment of PD symptoms in the long-term. Particularly, we pretend provide evidence that allow optimize the use of BoNT-A, defining optimal concentrations and periodicity of treatment, as well as the […]

The aim of the project is to design and test different chemical derivatives of betulinic acid as a treatment for cancer. It is well known that betulinic acid is able to specifically kill cancer cells, and so we have developed several derivatives to improve biochemical properties such as solubility or biodistribution but maintaining the toxicity […]

Each year approximately two out of every 1,000 Canadians experiences a heart attack. These patients are at increased risk for heart failure, a serious condition in which the heart cannot pump enough blood to meet the body’s needs. Heart inflammation that lasts too long following a heart attack may increase the risk of heart failure. […]

Mastitis is the most frequent and costly disease of dairy cows, with costs estimated at $670M/year in Canada. Mastitis is also the main reason for antimicrobial use in dairy herds, raising great concerns regarding emergence of antimicrobial resistance in critical pathogens capable of infecting humans. Implementation of management and nutritional strategies that can improve mammary […]

The normal rhythmic beating of the heart is controlled by a set of electrical signals. When these signals are scrambled and the heart is no longer beating regularly, it produces a medical condition known as cardiac arrhythmia. There are several types of cardiac arrhythmias, the most common one being atrial fibrillation (AF) that affects more […]

Peripheral arterial disease (PAD) is caused by changes in the wall of the blood vessels of the legs that make them narrow and stiff. The main causes of PAD are atherosclerosis and smoking. Unlike many other diseases, there is no blood test that is capable of detecting PAD. Instead, persons have to be referred by […]

When blood-vessels in the brain are damaged, substances can leak from the blood into the brain. This leakage can affect cognition and mental health, however there are currently no clinically-available tests for detecting such leakage. In this project we are continuing the development of a method for diagnosing subtle leakages in the brain’s blood vessels […]