Molecular mechanisms of synapse remodelling

In the CNS the majority of excitatory synapses are formed onto specialized structures known as dendritic spines which can undergo shape changes in the time frame of minutes to days. This inherent structural plasticity of dendritic spines even lasts into adulthood. It is still unclear why certain spines are more likely to be maintained, to provide a physical substrate for long-term information storage, while others are more structurally plastic. We have recently discovered a novel process by which mature dendritic spines can be maintained. The objective of the proposed study is to continue to contribute to the understanding of the rules that regulate the morphology and function of dendritic spines and develop novel targets for learning disorders.

Faculty Supervisor:

Rebecca Anne McKinney

Student:

SERGIO VILLICANA MUNOZ

Partner:

Discipline:

Pharmacy / Pharmacology

Sector:

University:

McGill University

Program:

Globalink