Evaluation of neuro-protective effects of novel water-soluble formulation of Ashwagandha root extract alone and in combination with water-soluble Ubisol Q10 using in vitro and in vivo models of Parkinsons disease

There is an increase in brain diseases like Alzheimers and Parkinsons diseases as the number of aged individuals is increasing. Currently there is no treatment available that can halt the progression of these diseases. Previous work has shown that a natural compound CoQ10 can prevent brain cell death. Similarly an Ayurvedic Herbal extract, Ashwagandh Root Extract has also shown promising results in some studies. In the present research project we will prepare a novel water-soluble formulation of CoQ10 and Ashwagandha Extract using a patented technology of Nextremedies Inc. We will test this novel formula in cellular (in petri dishes) and animal models of Parkinsons disease to find out if it can protect brain cells and halt the progression of Parkinsons disease. Successful completion of this project will lead to the development of a natural neutraceutical formula that can be used to treat Parkinsons disease.

Faculty Supervisor:

Siyaram Pandey

Student:

Caleb Vegh

Partner:

Next Remedies Inc

Discipline:

Biochemistry / Molecular biology

Sector:

Life sciences

University:

Program: