Analyzing neuroprotective properties of Lactobacillus rhamnosus HA114 in models of age-dependent neurodegeneration

Our aging population is burdened by decreased health and an increased risk of disease, including for many age-dependent neurodegenerative disorders like amyotrophic lateral sclerosis and Alzheimer’s disease (AD). There are no cures for these conditions, and according to the United Nations the number of people affected may double by 2040. Using simple genetic models of amyotrophic lateral sclerosis we have discovered a probiotic bacteria that delays disease onset, and this may be a new therapeutic approach for patients. We wish to test this probiotic bacteria in a mouse model of Alzheimer’s disease which, if protective, will set the stage for clinical studies.

Faculty Supervisor:

Alex Parker

Student:

Ericka Guitard

Partner:

Lallemand Health Solutions

Discipline:

Other

Sector:

Agriculture

University:

Université de Montréal