Analysis of TGF-? traps as effective immunostimulating cancer treatments

AVID200 is a TGF-? trap that specifically sequesters TGF-?I and TGF-?III to enhance antitumour immunity to inhibit tumor growth. AVID200 also avoids adverse side effect of depleted of TGF-?II. AVID200 is relatively short-lived in circulation, decreasing its capacity to exert desirable enhancement of anti-tumour immunity. To increase the effectiveness of TGF-? traps, a panel of candidate molecules that retain TGF-? isoform specificity and inactivating capacity, but with projected increased stability, have been generated by Formation Biologics.

Partnering to innovate for sustainable development – Canada’s Oil Sands Innovation Working Group

This project is part of a research program to develop a model of sustainability-oriented innovation processes. The model would allow Canadian organizations to innovate systematically and deliberately and become leaders in innovating for sustainable development. We will work to develop the model with Canada’s Oil Sand’s Innovation Alliance and its members: Cenovus Energy Inc., Shell Canada Energy and Suncor Energy Inc.

The application of UAV-based optical and thermal imagery on the estimation of intra-field soil and crop parameters

The efficient monitoring of soil and crop parameters is essential for crop stress evaluation and yield forecast in agriculture, yet most remote sensing studies focus on regional-scale soil and crop parameters estimation using satellite data. Satellite remote sensing is difficult to obtain both high spatial and temporal resolution data with a low-cost in field-scale. Currently, UAV-based remote sensing is a flexible and reliable approach could provide proper data for intra-field monitoring.

Investigation of magma conduits and their relationships to Cu-Pd mineralization at W-Horizon of the Marathon deposit, ON, Canada

Copper and palladium (Cu-Pd) mineralization at the Marathon Deposit are associated with gabbro rocks. It is fundamentally important to be able to distinguish among the different types of gabbros, because only those of the Marathon Series are host to mineralization. This is accomplished through logging drill core, whole rock geochemistry and mineralogy.

Resource potential of the Post Creek Property, Sudbury, Ontario

Sudbury represents the site of a meteorite impact structure originally greater than 200 km in diameter and that formed 1.85 billion years ago. Despite the proven and potential economic benefits of resource development at Sudbury, there are still major outstanding questions concerning our understanding of the structure and its ore deposits. A series of objectives have been composed concerning the origin of Sudbury Breccia, host to footwall vein deposits, and Offset Dykes at the Post Creek locality and their mineralization.

Hydrolytic de-polymerization of hydrolysis lignin using alkaline catalysts: effects of process parameters and optimization

Hydrolysis lignins (HL) are a byproduct from acid or enzymatic biomass pretreatment processes such as the ones employed in cellulosic sugar and/or ethanol plants. They are mainly composed of lignin , unreacted cellulose and mono and oligosaccharides.

Innovating towards the Circular Economy

The Canadian paint and coating industry had long established programs to collect residual paint from the household and recycle it into marketable products. By doing so, the industry protects the environment by recycling a significant amount of resources which used to end up in landfills as waste. However, such programs are currently costly for both the companies and consumers, due to extra costs of collecting and recycling.

Real-time multi-class object recognition for municipal waste collection

The use of garbage trucks with “robot arms” for municipal waste collection is becoming more and more common in Ontario and across North America. However, these “robots” have very little capability. In our collaboration with Waterloo Controls, we are working to automate the process of garbage collection. Rather than requiring the operator to acquire the truck, then steer the robot arm to pick up the bin, we are working to add automatic capability.

Group IT usage, diversity and innovation

This proposal is part of a larger research program that aims to study the relationships between IT usage for communication, diversity in social and technical knowledge, and innovation in groups. We have developed a research framework based on social network theories to suggest two different mechanisms for relating diversity and IT usage to novel idea generation and implementation. Our findings will help the partner organization to improve its capability to innovate by better forming and managing diversity within and across group in the context of innovations labs.

Process Development of Volatile Cobalt ALD Precursors

Cobalt thin-films have found widespread applications in microelectronics devices; such as liners in copper interconnects, wetting layers, and caps, in addition to applications for magnetic devices and CoSi2 contacts. CVD and ALD techniques are typically used to achieve cobalt films between 2-5 nm thick with excellent conformalities and negligible resistance increase. Leading precursors for cobalt thin-film deposition include cyclopentadienylcobalt dicarbonyl and dicobalt(hexacarbonyl)tert-butylacetylene.