Versatile applications of a safe and efficient peptide in gene/drug delivery - Year Two

Gene therapy is one of the most attractive new therapeutic strategies in the treatment of multiple diseases. However, to apply gene therapy in clinic, an efficient and safe delivery system must be developed to transport these therapeutic reagents to target organs. The existing gene carriers suffer from either high cytotoxicity or immunogenicity problems, which will cause severe side effects when used in human. The new peptide based delivery system we developed demonstrated better performance and lower toxicity than the commercialized product on market.

Evaluating the prospective benefits of physical demands description (PDD) data created from job simulations

Every job at Ford Motor Company should have an associated document describing the physical demands (i.e., lifting, climbing, pushing, etc.) required in that job. This information is important to select job candidates with the right blend of capabilities to be able to safely meet these demands. Perhaps more importantly, this information also provides a benchmark to guide health care providers in helping injured workers rehabilitate their capabilities so that they can again return to their job, safely meeting the job’s demands.

RF Resonant Chemical Sensor System for Biomarker Detection and Biomedical Applications

Sober Steering is developing a wearable alcohol sensor system that communicates with a vehicle to prevent drunk driving. The FitBit-style wearable device will communicate wirelessly with a Sober Steering module located behind the dash of the vehicle to provide interlock functionality and instant alerts. The wearable alcohol sensor system will be monitored and controlled by a smart phone app (ideally controlled by parents or fleet vehicle dispatch). The proposed project aims to further develop sensors capable of providing alcohol sensing functionality for the wearable device.

Extrusion of Metal Matrix Composite material: orientation of reinforcements and transfer of properties

The aim of this project is to develop and characterize metal matrix composite materials for applications in the field of power electronics and automotive. The material under study are constituted by a copper or aluminum matrix, reinforced by carbon (fibers or platelets) and it is known that the composite properties depend on the orientation of the reinforcements. The objective of this research is to study and to evaluate the effect of a deformation (e.g extrusion) of the material on its thermal, electrical and mechanical properties.

Scaling Geocontextualization

Urban design and development is an iterative process that involves community engagement and multiple feedback cycles. Advances in internet technologies and web mapping technologies has made it possible to display design plans on websites and to collect feedback on specific locations or aspects of the provided design. Using web mapping applications to feedback from the community is formally known as facilitated volunteer geographic information (FVGI).

Flexible In-Home Caching for Video Streaming Services

NightShift optimizes customers' bandwidth usage when using streaming services. It does this by taking advantage of off-peak bandwidth availability to cache digital media content
addressing both problems of limited bandwidth (which impacts real-time streaming) and bandwidth quotas (which can result in bandwidth throttling or overage charges). The goal of
this research is to explore interfaces that allow end-user control of local storage and download while still preserving digital rights security and the platform (e.g. Netflix) experience
of viewing content. In particular, we will explore:

Development of Graphene Modified Cathode for Next Generation Aqueous Rechargeable Lithium Batteries

Aqueous rechargeable lithium battery has received great attention recently due to the less toxicity, lower cost and higher safety compared to the non-aqueous systems. When using the commercially available lithium manganese oxide as active materials, there are demands in suppressing manganese dissolution and graphite consumption in the cathode. As a potential solution to achieve these goals, in this proposal, two dimensional graphene materials are integrated on the surface of the cathode, forming a hybrid cathode aqueous battery.

Conversational Response Generation with Linguistic Context and Emotional Context

The objective of this project is to develop methodologies for automatically generating responses in a natural language to converse with humans. Responses directly generated from the question-answer database are inflexible and cannot meet users' needs. On one hand, the responses should take into account the previous utterances that can keep a conversation more active. On the other hand, the responses should be appropriate for the emotions conveyed in a conversation that can make a conversion more user-friendly.

Development of new on-site sampling, high-throughput and high sensitive analysis for determination of small molecules in saliva

Saliva is a promising alternative specimen since it is easy and non-invasive to collect, and available at any time. Solid-phase microextraction (SPME) has been recently introduced as a green, simple, fast and sensitive sample preparation technique for high-throughput and in vivo analysis of drugs in various biological fluids, including saliva.

Drinking Water Treatment Infrastructure: Responding to Climate Change and Increasingly Variable Source Water Quality - Year two

As a result of climate change and other pressures that result in “extreme events” like wildfire and flooding, many
drinking water utilities are at risk of potentially catastrophic failure and need treatment adaptation strategies to
prepare for increasingly variable and potentially rapid deterioration in source water quality. Currently there are no
recognized tools for evaluating the anticipated impacts of such events on water treatment plant operations. This
research will enable Stantec Consulting Ltd.