Dual inhibition of CA9 and CA12 as effective novel anti-cancer therapy

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect in 2D/3D systems and will move to preclinical/clinical trials upon successful in vitro validation.

Engineering Synthetic D-Proteins as Novel and Transformative Molecular Therapeutics Against Cancer Targets

Proteins can exist in two forms: left-handed (L) or right-handed (D); however, for indeterminate reasons life on this planet only uses the L-form. When studied in more detail, both protein forms possess identical physiochemical and biological properties. Yet, D-proteins show minimal proteolytic degradation and fail to elicit immune responses in animals, due to their unnatural arrangement for recognition in biological systems. Accordingly, the proposed project seeks to develop synthetic D-proteins as biopharmaceutical molecules.

Web-based Goal Management Training™ in older adults with cognitive impairment: a randomized-controlled trial examining feasibility and efficacy - Year two

As the Canadian population is aging, more and more Canadians will show cognitive decline. Aging and certain types of
neurological disorders is often associated with deficits in executive functions: goal maintenance, planning, task
switching and attention. These functions are critical for the maintenance of functional independence. Few validated
rehabilitation approaches for these types of deficits exist. One rehabilitation approach, Goal Management Training™
(GMT), has shown promise. In its standard implementation, GMT is led in small groups.

Assessment of Tissue Viability in the Lower Extremity of Diabetic Patients

In Canada, people with diabetes are 20x more likely to have an amputation of their lower limb than the general population. Having a diabetic foot ulcer (DFU) increases the risk of amputation by 50%. Early assessment and treatment of a patient’s DFU can prevent amputation, but patients with diabetes often lose sensation in their limbs, and may not even realize they have a DFU. There are currently no easily accessible early warning tools for DFUs. To address this need, we have invented a non-invasive device for DFU assessment, and are now optimizing it for use in patients at St.

Resilience of modern skyscrapers subject to natural hazards - Year two

The structural performance of skyscrapers subjected to natural hazards such as strong winds and earthquakes has significant effects on the resilience of a city because of the recent boom in the construction of skyscrapers around the world. However, resilience is currently not explicitly considered in the design of tall buildings. Studies show that modern tall buildings can suffer significant damage due to natural hazards and they might need to be closed for up to 2–3 years for repair. This has serious socio-economic repercussions.

Building Information Modeling Enabled Dependency Risk Analysis for Resilient Building Design and Operation

This project integrates building information models (BIM) with RiskLogik's proprietary risk and resilience solutions to progress the design of complex buildings. This is accomplished by supporting the improved design of the interrelationships between building systems, such as mechanical, electrical, communications, and security systems and the operations that reside within the buildings. As a result, performance is improved by ensuring a resilient network of interconnections that reduces system conflicts and cascade effects.

Measuring Knowledge Translation in Academic / Industry Collaborations

As manufacturing and resource-based industries face growing challenges, Canada’s future increasingly depends on advances in and sustainability of knowledge organizations. Knowledge-based workers comprise a growing proportion of the workforce today. More often than not, they work in the context of large-scale expert networks, spanning across different disciplines and organizations. They rely on software technologies for their discipline-specific activities, the coordination of their activities, and their communication with each other.

Investigating the use of Virtual Reality and Augmented Reality for Digital Content Creation with freehand 3D Sketching

The project involves conducting a study to evaluate human performance in executing simple drawing tasks like drawing curves and lines from various directions. The study will help ascertain the accuracy and ergonomic aspects of 3D drawing. We will then use the results of the study to design a 3D sketching system combining augmented reality glasses with traditional drawing tablets. The tablet can provide a physical constraint to aid drawing tasks while also reducing the amount of fatigue the artist faces.

Using systems engineering as a framework to evaluate a Pre-residency program for international medical graduates

Evaluation is a key element to assure the high quality of programs. The Pre-Residency program is meant to prepare the international medical graduates to be at the same level as any locally trained Medical graduate in Canada for their specialty training rotations. In this project we are using an innovative engineering approach to conduct an evaluation of the Pre-Residency program. Our goal is to provide a more objective evaluation using engineering to help assure the high quality of the Pre-Residency training program offered by the Touchstone Institute.

Development of Li-Ion cells/batteries for low temperature applications

Increases in gasoline price and greenhouse gas emissions have spurred the growth of hybrid electric vehicles (HEV) and pure electric vehicles (EVs). Rechargeable Li-ion batteries are the leading candidate for powering these vehicles due to their high energy and power density properties relative to other batteries. However, their energy and power capabilities are substantially reduced at low temperatures, posing a technical barrier for market penetration of HEVs and EVs.

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