Development of Cell-Based Functional Assays to Accelerate Commercialization and Therapeutic Application of Recombinant Antibodies

Antibodies are used for treatment of many diseases, including cancer. Within the human immune system, antibodies fight invading bacteria and viruses. We have devised a way to make high-quality antibodies in the laboratory and target them to specific disease-related proteins that have been identified by the scientific community and in our lab. Ensuring that these antibodies work in cells the way we intend them to in the body is a critical step of identifying their potential as therapeutic agents and also in the commercialization process.

Scale-up of Bioaugmentation Cultures and Development of Delivery Strategies and Monitoring Tools for Anaerobic Benzene and Alkylbenzene Bioremediation

The overall objective of this project is to scale up and demonstrate the utility of novel bioaugmentation cultures for BTEX compounds, and associated diagnostic tools to properly deploy the technology. The intern will lead the project team to develop gene-based biomarker tools applicable to the bioaugmentation cultures and apply these tools to samples submitted from bench scale treatability testing and real world field samples.

Rapid Health Impact Assessment On Introducing Permanent High Occupancy Vehicle Lanes and High Occupancy Tolls Lanes In the Greater Toronto Area

The WHO defines health as “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity”. The holistic nature of this definition provides the basis for an all-encompassing evaluation of health, which is the guiding principle behind health impact assessment (HIA). An emerging area of public concern in Canada is the assessment of the potential impact that transportation infrastructure has on human health. HIA is ideally placed for such an assessment.

Identifying the molecular mechanisms of neutrophil extracellular trap (NET) formation and screening NETosis-suppressing drugs to treat cystic fibrosis lung disease

Recent discoveries show that neutrophils mainly die by formation of neutrophil extracellular traps (NETs) in Cystic Fibrosis airways. Therefore determining mechanism and identifying FDA-approved drugs that inhibit NETosis could provide novel options to treat CF lung disease. We aimed to do the comparative gene expression analysis during NETosis induced by different NET inducing agents (PMA,LPS,A23187) in CF neutrophils. Furthermore to translate the findings for therapeutic targets, screening of large scale drugs, kinases and specific pathways inhibitors associated with NETosis are required.

Evaluation of the CACE Homecare Curriculum

In January 2016, the Centre for Ambulatory Care Education (CACE) at Women’s College Hospital completed the Homecare Curriculum. This online, simulation-based program is designed to help personal support workers, nurses, and rehabilitation professionals provide better care for older adults who wish to stay in their homes. The program presents learners with 3 virtual home environments and 3 patient profiles. Alone, or with a team, users navigate these virtual homes, learn about home-based care and complete quizzes that test their comprehension of the material.

Development and Evaluation of a Life Threatening Infections Point-of-Care Triage Test for the Fionet System

Febrile syndromes are among the most common causes of global illness accounting for approximately two billion episodes annually. However, most infections are self-limited and only rarely do they progress to critical illness. Our current inability to rapidly identify the small proportion of individuals who will progress to life-threatening infections (LTIs) is a major barrier to effective triage and precision management of serious infections. Our research has identified biomarkers with high diagnostic accuracy for LTIs.

Synchrotron investigation of water distribution in fuel cells and correlation to properties and performance

Polymer electrolyte membrane (PEM) fuel cells convert hydrogen and oxygen into electrical power through an electrochemical reaction, producing water and heat. These fuel cells have been considered for automotive powertrain applications. In this proposed work, a set of varying PEMFC materials will be investigated to advance the performance of PEM fuel cells. The fuel cells will be run under a wide range of operating conditions, including temperature, pressure, inlet gas relative humidity as well as compression pressure.

Optimization and compatibility study of a pH-responsive terpolymercomposite membrane for controlled release dosage forms

A new film coating that can respond appropriately to different pH conditions of the stomach and small intestine (GI tract) was successfully prepared by combining pH-responsive nanoparticles with ethylcellulose polymer. However, the performance of the composite membrane has not been optimized for controlling drug release in the GI tract. Therefore, improvements are to be made through experimental design, such as central composite design, to find the appropriate composition of the nanoparticles to achieve the best overall combination of coating properties.

Development of dual antibody therapies for cancer

Cancer is a devastating disease defined by genetic changes that result in the activation of proteins that encourage cell growth or prevent cell death. Modern oncology aims to specifically target these tumour-promoting proteins, which has the secondary benefit of leaving normal cells unharmed, unlike chemotherapy. Recently, a number of drugs that specifically block tumour-promoting proteins have been produced, yet the results are underwhelming: most targeted therapies show an initial benefit, followed by the development of resistance.

My Wellness Journey: A Health Promotion Study for Children and Youth with Disabilities

The purpose of this project is to support the development of wellness-focused interventions, including weight management, mental health and social well-being for children with intellectual and developmental disabilities (IDD). To date, the focus of health promotion interventions have primarily focused on typically developing children and adolescents, rather than those with IDD.