Programming of long-term digital memory storage devices is currently not an optimised process. This is due to the fact that the exact physical mechanisms that allow for a data bit to be reliably stored and read are not well understood. As a result, in order to produce high quality, long-lasting, reliable memory cells, the manufacturer must perform extensive testing and
iterative modifications on each generation of products. Our project aims to develop a software model that simulates the physics and chemistry of memory device structures on an atomic level.
Membrane proteins such as ion channels, transporters or G-protein coupled receptors (GPCRs) are excellent but difficult drug targets involved in a large number of life-threatening diseases and conditions. These proteins, over-expressed and essential for disease onset and progression, are naturally targeted by toxins from venomous organisms. During evolution, these toxins have been optimized to efficiently target physiologically-relevant proteins involved in ion channel opening or closure, thus incapacitating the prey or defending against predators.
Signaling through the Eph family of cell surface receptors is crucial for embryonic development and the maintenance of adult tissues. Given the central role of the 14 Eph receptors in controlling cell fate, it is not surprising that they also play a central role in oncogenesis and other pathological conditions. However, the signaling mechanisms of Eph receptors are extremely complex, and developing an effective therapeutic intervention for a particular disease requires a comprehensive understanding of Eph function.
Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect in 2D/3D systems and will move to preclinical/clinical trials upon successful in vitro validation.
Proteins can exist in two forms: left-handed (L) or right-handed (D); however, for indeterminate reasons life on this planet only uses the L-form. When studied in more detail, both protein forms possess identical physiochemical and biological properties. Yet, D-proteins show minimal proteolytic degradation and fail to elicit immune responses in animals, due to their unnatural arrangement for recognition in biological systems. Accordingly, the proposed project seeks to develop synthetic D-proteins as biopharmaceutical molecules.
As the Canadian population is aging, more and more Canadians will show cognitive decline. Aging and certain types of
neurological disorders is often associated with deficits in executive functions: goal maintenance, planning, task
switching and attention. These functions are critical for the maintenance of functional independence. Few validated
rehabilitation approaches for these types of deficits exist. One rehabilitation approach, Goal Management Training
(GMT), has shown promise. In its standard implementation, GMT is led in small groups.
In Canada, people with diabetes are 20x more likely to have an amputation of their lower limb than the general population. Having a diabetic foot ulcer (DFU) increases the risk of amputation by 50%. Early assessment and treatment of a patients DFU can prevent amputation, but patients with diabetes often lose sensation in their limbs, and may not even realize they have a DFU. There are currently no easily accessible early warning tools for DFUs. To address this need, we have invented a non-invasive device for DFU assessment, and are now optimizing it for use in patients at St.
The structural performance of skyscrapers subjected to natural hazards such as strong winds and earthquakes has significant effects on the resilience of a city because of the recent boom in the construction of skyscrapers around the world. However, resilience is currently not explicitly considered in the design of tall buildings. Studies show that modern tall buildings can suffer significant damage due to natural hazards and they might need to be closed for up to 23 years for repair. This has serious socio-economic repercussions.
This project integrates building information models (BIM) with RiskLogik's proprietary risk and resilience solutions to progress the design of complex buildings. This is accomplished by supporting the improved design of the interrelationships between building systems, such as mechanical, electrical, communications, and security systems and the operations that reside within the buildings. As a result, performance is improved by ensuring a resilient network of interconnections that reduces system conflicts and cascade effects.
As manufacturing and resource-based industries face growing challenges, Canadas future increasingly depends on advances in and sustainability of knowledge organizations. Knowledge-based workers comprise a growing proportion of the workforce today. More often than not, they work in the context of large-scale expert networks, spanning across different disciplines and organizations. They rely on software technologies for their discipline-specific activities, the coordination of their activities, and their communication with each other.