In order to properly manage the risks associated with trading complex financial products, CIBC carries out computationally expensive calculations to properly assess their exposure to various market factors. To make these computations more feasible, it is of interest to find new, efficient and approximate mathematical formulas to compute such exposures. It is also important to complement these new formulas with rigorous justification of the resulting approximation error. Such justification will provide confidence to practitioners at CIBC who will use these formulas in the future.
Ventilator assisted individuals (VAIs) living at home are frail and generally cannot perform most daily activities. This is similarly the case for the palliative population of those with amyotrophic lateral sclerosis (ALS). Although these individuals prefer to live and die at home, the family members who care for them often experience stress and poor health. Peer support can mitigate health declines by decreasing caregivers isolation/stress and increasing their sense of control. However, no peer support programs are designed to meet these caregivers complex and unique needs.
"Poor efficacy and unpredictable toxic effects are leading causes of removal of a drug from the market. Many drugs act unpredictably in patients because they are tested in labs using cells grown in plastic dishes and animals that poorly mimic humans.
Administration of supplemental oxygen through medical air is a life-supporting measure essential for the management of severe primary respiratory conditions as well as secondary lung injury due to systemic insults such as trauma and sepsis. This medical air is often produced on site through devices which draw, compress and filter outside air in order to redirect it into buildings. However, depending on the outdoor conditions, the state of the ventilation system or the presence of microorganisms, this air can be contaminated.
Neisseria meningitidis (Nme) is a bacterial pathogen that often colonizes the upper respiratory tract of humans without symptoms, but which may also develop into rapidly-progressing sepsis and meningitis that can be fatal. Nme has evolved elegant means to specifically interact with human cells and proteins in order to colonize, survive and the evade host immune system. In partnership with Vaxiron Inc., we are developing a novel class of vaccines that target systems involved in Nme acquisition of the essential micronutrient, iron, during infection.
In water quality management, mathematical models are used to understand ecological processes, to predict aquatic ecosystem dynamics, to evaluate management alternatives/climatic scenarios, and to support the policy making process. Environmental models involve substantial uncertainty due to their structure, unknown parameters, and errors associated with calibration data and other inputs. This research program aims to address the urgent need for credible modelling tools by combining environmental mathematical modelling with Bayesian analysis.
Kobo’s Big Data Director Darius Braziunas says he knew early on that to stay competitive in the e-book world Kobo would need to collaborate with university researchers to take their products to the next level.
Over the past 15 years, People for Education has conducted a survey of Ontarios publicly funded schools. From this large-scale survey, People for Education produces research reports on public education in Ontario that are widely disseminated to the public and have been instrumental to informing educational policy in the province.
The current survival times for breast cancer patients with brain metastasis range from 2 to 16 months suggesting a strong need for improvements in their therapeutic care. Although radiation therapy is the standard of care for these patients, combination with chemotherapy has demonstrated promising therapeutic benefits. The hypothesis of this research program is based on the belief that optimizing combination of radiation and chemotherapy has the potential to significantly improve the treatment outcome for patients with breast cancers that have metastasized to the brain.
This project aims to assess how the use of the novel ultra-short echo-time (UTE) MR imaging technology can add value to conventional MRI for detection and quantification of blood products in hemophilic joints. We will test this novel technology in joints of hemophilic patients with different stages of arthropathy presenting with blood products at different stages of degradation as compared with existing MRI sequences.