Formulation of Cationic Peptides by Hyperbranched Polyglycerols for the Treatment of Chronic Rhinosinusitis

Chronic rhinosinusitis is a common condition in which the cavities in the nasal channel become inflamed and swollen. This condition interferes with drainage and causes mucus to build up. Delivery of the positively charged proteins containing short chains locally to the nasal area can be used for the treatment of this problem. This proposal suggests synthesis and characterization of negatively charged polymeric systems with specific modifications to bind to these proteins and stabilize them.

Modern tools for selecting disease-resistance traits in honey bees

Over the past six and a half years we have developed a way to measure disease resistance in honey bees using a molecular diagnostic approach, similar to the tests done every day in hospital laboratories. We have then used this method to selectively breed bees that are, indeed, more resistant to disease. This is akin to the selective breeding humans have practiced for millennia on all our agricultural crops and livestock, only using modern tools. It is not genetically modifying bees.

Pool-riffle design for river restora

Professionally practicing Civil Engineers and Earth Scientists engage in stream restoration actions in order to enhance freshwater habitats for salmon, trout, and a variety of other species. There is a wealth of procedures and standards available to help practitioners develop design plans. However, there is a lack of specific guidelines to help identify stream reconstruction details that will give the overall effort a greater likelihood of meeting performance expectations and criteria after the project has been constructed.

Web-based mobile mental health technology in an acute care setting

The use of mobile technology is on the rise including access to mental health-related applications and websites. There is a wealth of information available and numerous intervention strategies focused on treatment and support for mental health concerns. However, inpatient psychiatry often discourages patients' use of electronic technologies and web-accessible mobile phones. The proposed study involves brief interviews with patients admitted to inpatient care at St.

In-silico identification of driver alterations and prediction of therapeutics targeting actionable drivers in prostate cancer

Cancer arises as a result of deleterious aberrations in the DNA, RNA and proteins of cells. The accumulation of genetic abnormalities, over lifetime, perturbs critical functions of cells, which may ultimately give rise to tumor. However, vast majority of these aberrations are not essential and only small fractions, known as “driver” genes, are critical for tumor growth. Identification of driver aberrations is a challenging task, but is critical for optimal cancer management. Prostate cancer (PCa) is the most common cancer to affect Canadian men.

Sustainable Urban Development: Homebuyer Expectations and Implementation Challenges

The main objective of this research project is to synthesize and evaluate the published and grey literatures on consumer perceptions of green real estate development and sustainable community design features. Current research on homebuyers perceptions, priorities, motivations, and willingness-to-pay has yet to be consolidated. The complex nature of these topics scatters research across several disciplinary sectors, making it difficult to integrate the data and make an informed decision for sustainable real estate investment.

An Evaluation of the Sam Sullivan Disability Foundation

The Sam Sullivan Disability Foundation (SSDF) is a fundraising entity supporting six not-for-profit societies that provide opportunities for social engagement for people with disabilities. The six societies provide design opportunities for accessibility solutions; connect people with employment, training, and social opportunities in the community; and make sailing, music, gardening, and the great outdoors more accessible. This research project will look at the impact and effectiveness of the SSDF programming on the lives of people with disabilities.

Respirable Crystalline Silica: A Risk Assessment Tool for the Construction Sector

Silica is a known lung carcinogen and causes silicosis, an irreversible fibrotic lung disease. RCS is a major problem in the construction sector because of the high content of silica in construction materials. New tools are needed to help the construction industry in recognition, evaluation and control of RCS. The intern will develop an on-line tool that will provide the over 40,000 BC construction employers with access to archived silica exposure measurement data to enable quantitative risk assessment and appropriate control selection.

Designing a Usable Software Lifecycle Traceability Language Part 2

Teams of specialized workers develop most software. For example, one team may specialize in the requirements that describe what the software is to do. Another team may specialize in producing the software itself. Yet another team may specialize in determining whether the software meets the desired requirements.

Development of a renewable and small scaled heat and power generation system for remote location using woody biomass as fuel

The key objective of this research is to develop a unit for combined heat and power production using biomass feedstock that can be used in remote areas where no grid power is available. Canada as the second largest country in the world, has a great potential for such units. Aboriginal communities or remote work facilities are only two possible applications for this technology. The existing heat and power generation system mostly rely on diesel and natural gas.