The alignment of the dissertation and the CE in terms of preparing students as researchers in today?s environment or for innovative work outside the academy is in question. The purposes and structures of these basic PhD components have not changed significantly since the origin of the modern PhD, which was developed primarily as a vocational degree for the professoriate.
Neuropsychiatric disorders, including depression and anxiety, represent prevalent and disabling medical conditions affecting society. Despite the urgent need for novel pharmacotherapeutics to treat these conditions, there are few new drugs in development by the pharmaceutical industry. Cannabis has been used by humans for thousands of years to self-medicate a range of different neuropsychiatric symptoms, although few studies have addressed this issue in a scientific manner.
Merging different sub-companies into TELUS caused some of customer records to be repeated through the merged data-set. Algorithms are needed to determine the duplicate records. Currently a deterministic algorithm is being used in TELUS. In this project, we will investigate if machine learning can help to detect duplicates. Solving this problem has several parts. We have to preprocess the data and select some features from the TELUS records that help us in our model. A probabilistic model should be selected, implemented and tuned.
The complement system is an essential component of innate immunity, but also causes self-damage when the system is aberrantly activated or self-protective capacity is exceeded. There are many conditions where failure to protect against self-damage from the complement system has been implicated in the pathology, including Alzheimers disease, Parkinsons disease, Lou Gehrigs disease, paroxysmal nocturnal hemoglobinemia, atypical hemolytic uremia syndrome and age-related macular degeneration.
In this project, we will establish biomarkers that objectively reflect the severity of injury, measure its progression, and predict neurologic outcome after acute spinal cord injury (SCI). This will be accomplished by comprehensively analyzing blood and spinal fluid samples from acute SCI patients. In addition, we will conduct a parallel experimental study in a large animal model of SCI with a similar analysis of blood and spinal fluid samples.
Modern weather forecasts are made by computers that solve the complicated equations for air motion, heat, and moisture. Different computer codes, called weather models, use different atmospheric approximations, creating slightly different forecasts. This forecast diversity is good, because the average of all forecasts is often the most accurate, and the spread between forecasts measures uncertainty.
Reduced number of insulin producing ?-cells in pancreas due to increased ?-cell death is a key defect in diabetes that eventually leads to elevated blood glucose levels and life-time treatment with glucose lowering drugs or daily insulin injections. Thus, finding therapeutic approaches to prevent the decrease in the number of insulin producing ?-cells in diabetic patients either by reducing ?-cell death or by increasing their proliferation is of great importance.
This project aims to validate and optimize drugs to treat heart rhythm disorders. The heart is a complex organ that uses tiny electrical signals to maintain a healthy rhythm. When these electrical signals are disturbed, it can change the regular rhythm, which can result in life-threatening consequences such as sudden cardiac death. Here, I will visualize one of the components of the heart that is responsible for the electrical signals, a specialized protein known as the sodium channel. I will look at the three-dimensional structure of this component both with and without drugs bound to it.
To perform a complete molecular analysis of muscle invasive bladder cancer (MIBC) before and after pre-operative chemotherapy to find changes responsible for resistance to treatment. Analysis will include a combination of DNA sequencing, RNA expression analysis and quantification of protein. Together this information will reveal the molecular landscape for these tumors.
At the moment, BC has no comprehensive climate change curriculum in high schools, and educators lack coordinated materials to support its teaching. In an effort to narrow this gap, the Collaborative for Advanced Landscape Planning (CALP) at the Faculty of Forestry, UBC partnered with the Delta School District, to develop an educational and compelling videogame Future Delta 2.0 (FD2), which brings together methods from commercial gaming a participatory research to address climate change science in an innovative place-based game environment.