Data-driven approach to establish a design space for raw materials properties and manufacturing conditions for pharmaceutical drug stability assurance

Pharmaceutical companies are required to perform stability testing of their drug products by regulation. A drug product that succeeds on stability testing means that its identity, potency, and purity remain within pre-established limits over its shelf life. Nowadays, drug products are more frequently reformulated in response to a highly competitive market, new research discoveries and the availability of new suppliers of raw materials.

Système d’information de mesurage énergétique (GeoStat)

Le projet est l’utilisation de diverses méthodes pour déterminer la capacité thermique des matériaux.
Les applications directes sont :

Assessing team functional state in emergency response

The need for better measurement of emergency response teams has been recognized as one of the key challenges that characterize the field of team work studies. Ideally, when assessing team performance, one should combine information about the nature of the team (e.g., what is the team structure?) and about its members (e.g., is one of the member exhausted?). This challenge is particularly hard to address in the context of emergency response, due to the inherent complexity and dynamism of the domain. For instance, how do you assess team member’s level of fatigue when deployed in the field?

Industrial Applications of Frequency Comb Lidar

The goal of the proposed research project is to explore applications of frequency combs, for which laboratory applications have already been demonstrated, in an industrial setting. The research will be mainly focused on chemical sensing of stack emissions for monitoring purposes. As a secondary objective, the use of frequency combs in vibrometric measurements for structural health monitoring applications will also be explored. For the most promising applications, the project will be concluded with work on a development roadmap for a commercial platform.

Increasing the expression of frataxin with the CRISPR system

Friedreich is an hereditary disease, which in due to a mutation of the frataxin gene. This mutation leads to a reduced production of the frataxin protein. This leads to oxidative stress and death of the cells. The death of the neurons and cardiomyocytes are responsible for progressive severe neurological and cardiac symptoms.

Transcriptomic analysis of follicular somatic cells after vitamin supplementation using Vicomb® feed additive in bovine Year Two

In cattle, energy requirements after parturition increase exponentially, primarily, due to increase in milk production. Negative energy balance hampers reproductive efficiency, inflicting heavy economic losses to dairy industry. Poor reproduction is the most important cause of culling dairy cows. Feed supplementation with vitamins improves energy balance. Also, observations in humans indicate that folic acid and vitamin B12 improve oocyte quality and pregnancy establishment.

"Planification de la distribution en contexte de livraisons quotidiennes sous contraintes defenetres de temps Year Two *Renewal, previous title ""Planification de la distribution en contexte de livraisons quotidiennes sous contraintes de fenetres de temp

Le premier objectif de ce projet est de developper un algorithme de resolution du probleme de planification de tournees de livraison a un niveau fonctionnel. Par fonctionnel, nous entendons integrer toutes les contraintes operationnelles du secteur industriel du partenaire afin que l'algorithme soit exploitable dans un contexte concret. Pour ce faire, une collaboration tres etroite entre le partenaire et le chercheur est necessaire.

Transcriptomic analysis of follicular somatic cells after vitamin supplementation using Vicomb® feed additive in bovine

In cattle, energy requirements after parturition increase exponentially, primarily, due to increase in milk production. Negative energy balance hampers reproductive efficiency, inflicting heavy economic losses to dairy industry. Poor reproduction is the most important cause of culling dairy cows. Feed supplementation with vitamins improves energy balance. Also, observations in humans indicate that folic acid and vitamin B12 improve oocyte quality and pregnancy establishment.

Vulnérabilité des forêts et des activités forestières aux changements climatiques

Les feux de forêts naturels sont les perturbations majeures à la base de la dynamique végétale boréale. Les changements climatiques induiront une augmentation des régimes de perturbations. Les régimes de perturbations, la structure et la composition forestière pourraient se diriger vers une variabilité naturelle différente de celle connue précédemment.

Metallogeny of Rare Earth Element deposits in Quebec

The one-year project will investigate the geological, geochemical and geophysical properties of three Rare Earth Element (REE) deposits in Québec. Each of the selected deposit is representative of a class of REE mineral deposits. The project will provide new insights in the origin of the three types of REE mineral deposits. This new understanding of the formation of REE mineral deposits will be transferred to the industrial partners and will be used to improve the odds of discovering REE resources in Québec and Canada.

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