Heart failure (HF) is one of the leading causes of hospitalization and rehospitalization in older adults, yet the majority of HF-related readmissions are preventable if patients can manage their treatment at home. One method to help patients who require extra assistance in following their treatment is through mHealth applications. However, these applications are not usable for many older patients due to their complicated design.
In the health technology assessment (HTA) process, cost- effectiveness analysis gets more attention, however over last decade, the budget impact analysis (BIA) has certainly become more important to the subsequent steps, including the adoption decision. The first Canadian BIA Guidelines was published by Patented Medicine Prices Review Board (PMPRB) in 2007. According to the results of a recent survey with regards to validate the practicality of the guidelines for policy makers, an update was recommended in order to reflect the changes that have occurred in the pharmaceutical industry.
Glioblastoma multiforme (GBM) is the deadliest form of human brain tumors, systematically recurring despite multimodal treatment. As a consequence, the average patient survival is less than 15 months, and is thought to be linked with the presence of brain tumor stem cells (BTSCs) that are implicated in treatment resistance. GBM BTSCs are radiotherapy and chemotherapy resistant, and BTSCs escaping treatment may explain tumor relapse. In the current era of precision medicine, targeted radiotherapy constitutes an attractive strategy for treating intractable disease.
Cellulose nanocrystals (CNCs) are natural bio-based nanoparticles that can be used to modify the viscosity and improve the performance of various fluids. For this reason, they are of interest to the oil and gas industry, where they can replace other expensive and non-biodegradable polymers that are commonly used. CNCs must first be modified so that they do not degrade or settle at high temperatures and pressures. To accomplish this, CNCs will be extracted from cotton using a variety of methods or by post-modifying the nanoparticle surface to have new chemical groups and new functionality.
This project concentrates on the scenario optimization method which does not need to make any assumption for the underlying asset distribution and directly incorporate such uncertainty into the objective or constraint functions through stochastic programming. The scenario optimization is performed under different parameters and constraints while Markowitz and Black-Litterman model are taken as the benchmarks to evaluate if the scenario optimization can outperform the traditional methods with the same input exchange-traded funds (ETF) data.
Recreational water sources are important commercial resources and activity hubs. Unfortunately, any public water source is prone to bacterial and viral contamination, which is a major concern for public health agencies. InnovoGENE Biosciences has a developed a simple test that can quickly determine the level of pathogens. Although this method has been rigorously tested in a laboratory, this test is unproven on the field. The intern has a significant understanding of the technology and is most suited to validate the assay and is capable of optimizing the assay for field use.
Antibiotics are the most widely prescribed drugs in children and its frequent use presents a real danger to its ongoing effectiveness. Probiotics are bacteria that, when administered in adequate amounts, may replenish âgoodâ bacteria depleted by antibiotics to maintain the normal bacterial composition in the gut. The aim of this study is to determine whether taking probiotics with antibiotics protects against shifts in the bacterial composition of the gut microbiota.
Medication errors are common in long-term care homes, as older adults are at an increased-risk of experiencing medication errors. Additionally, most older adults living in long-term care homes have dementia, and few can identify themselves; this increases the risk of a medication error. Tap2Tag Medical Ltd. offers the Tap2Tag Medical Alert Bracelet. The bracelet encompasses a personal health record which, once âtappedâ by a smartphone, loads a âprofileâ onto the web browser of the phone.
Increasing the productivity of agricultural fields is essential to secure our existing food supplies and provide for the growing world population. In this context, pesticides and fertilizers play an essential role in both increasing crop yields, as well as enhancing crop defenses against environmental stresses such as drought, pests, or diseases. However, the application of existing chemical pesticides and fertilizers can lead to potential downstream environmental issues.
Fibroproliferative disorders are the leading cause of morbidity and mortality worldwide. A large group of interstitial lung diseases (ILD) can cause progressive scarring of lung tissues, affecting the ability to breathe. Idiopathic Pulmonary Fibrosis (IPF) is one of the major forms of ILD and is characterized by a progressive decline in lung function. Although the pathogenesis of IPF is not completely understood, work from our group and others suggest that transforming growth factor beta 1 (TGF-?1) is involved in the fibrogenic process.