Memory impairment is the most common cognitive complaint among older adults. On the other side of the developmental spectrum, young adults that have been diagnosed with Autism Spectrum Disorders (ASD) have difficulty adapting flexibly to changing social circumstances. These memory and social deficits disrupt every day living. At present, promising interventions based on research using expensive and specialized equipment are reserved for clinical settings.
The analysis of protein-protein interactions is critical for understanding cell growth control, and how aberrant connections contribute
to cancer and other diseases. Mass spectrometry is a critical tool in this field, but sample complexity, instrument dynamic range and
resolution limit some applications. This project will evaluate the use of the SelexION ion mobility device and High Resolution TOF
with Zeno pulsing for enhanced separation and detection of cross-linked peptides from protein complexes and to detect posttranslational
modifications of proteins, specifically phosphorylation.
The bacterial transferrin receptor is considered to be a potentially efficacious candidate vaccine antigen against pathogens important in human disease and in animal husbandry. Previous data suggests that transferrin receptor-based antigens can elicit protection from both invasive disease and potentially from asymptomatic colonization. One major consideration when developing vaccines is the choice of adjuvant, a component able to influence the intensity, quality and breadth of the immune response.
Wildland fire fighting is a physically demanding public safety occupation. Front-line wildland fire fighters (WFF) must have an appropriate level of job-related fitness for safe and efficient work performance. Beginning in 2011, it was required that all WFF must demonstrate that they are capable of meeting the rigorous physical demands encountered during an initial attack response to a wildland fire. This decision led to the development of the Canadian Physical Performance Exchange Standard for WFF (WFX-FIT).
It is well known that an adequate and stable income promotes health. Material security (e.g., housing, food, and service access) may operate distinctly from income security, yet may also be critically important to health. Nevertheless, material security and its relationship with employment is not well understood, an important oversight in research among people who use illicit drugs (PWUD) given that the ongoing need to acquire drugs may disrupt the translation of income security into material security.
Medication used everyday to help cure various diseases, or even alleviate pain, ends up in the sewage system due to the less than perfect consumption of these medicines in the body and excretion of the unused portion. These compounds eventually find their way to the environment since the current treatment methods in wastewater treatment plants are not capable of complete elimination of pharmaceutical compounds. In the environment, pharmaceutical contaminants can harm aquatic species and potentially have negative effects on humans if they end up in drinking water sources.
Automated physiotherapy motion tracking system may improve clinical outcomes by providing subjective measures and continuous monitoring. A study into different metrics that PTs may find useful for diagnosis and a user interface study assessing the current usability of the Automated Rehabilitation System, a system being developed by Cardon rehabilitation, will be conducted. A method to model the central nervous system using controls will be investigated to see if fatigue can be detected, which is a useful metric to provide both patients and physiotherapists.
During surgeries, it is important to keep track of what is happening with the patient, the steps being taken during the surgery by the operating staff, and unforeseen events that occur. All the previous correspond to the surgical workflow. Keeping track of the workflow is essential to achieving a better and safer surgery. In the past, computational tools have been developed to track each step the surgeon takes during the surgery, and dividing the separate surgical phases. However, the adverse events have not been tracked.
Mobile health (mHealth) apps allow patients to practice self-care and manage their chronic diseases. Common functions in mHealth tools allow users to monitor their symptoms and mood, keep a thought diary, track medication use and trend information; this provides data that can be used to better understand patient behaviour to ensure that patient needs are being met. By using a user-centered design approach for app design, the patient experience is captured through understanding their goals and challenges as well as their journey in living with or recovering from chronic disease(s).
This series of projects will provide coaches and sport scientists with a greater understanding of the relationship between training and performance. While there are several methods for monitoring how much and how hard athletes train, how these can be best used to predict future performance is still in question. The sports of rowing and middle-distance running involve similar race demands, that being a full effort over 5-10 minutes.