Implementation and advancement of algorithm for extracting oxygen saturation data from multispectral analysis of the eye

To work on the development of a tool enabling the measurement of blood oxygenation in the eye in vivo, using non-invasive methods. More specifically, the student involved will work on the development, implementation, and advancement of an algorithm for the measurements of oxygen saturation (through oxyhemoglobin content) in the retina.

Plasma Surface Modification for Passive Microfluidic Immunoassays

Sensoreal’s patented technology allows them to perform complicated laboratory health testing procedures on a plastic microchip the same size as a credit card. The testing is done through the use of passive microfluidics, in much the same way as trees transport water to their leaves. A blood sample is placed in the loading port of the microchip and allowed to pass through the different regions of the device. Doing so reproduces the procedures that a blood sample would go through when tested in a laboratory, however the whole process takes place in only 30 minutes.

Exploring home range and habitat use during the breeding season of the Bicknell’s thrush (Catharus bicknelli) in New Brunswick Clear-cuts

The Bicknell’s thrush (Cathurs bicknelli) is a rare songbird with the most restrictive breeding range in North America. The Bicknell’s thrush spends its summer months breeding in high elevation, stunted growth forests – a habitat that the species specializes in. In New Brunswick, there has been a documented population decline of 11.5% per year since 2001. After having identified specific geographic areas where Bicknell’s thrush present, this project proposes using radio-tracking to describe individual’s breeding home ranges and extrapolate population size and densities.

Development of Fungal-Specific Stress Response Inhibitors for the Treatment of Fungal Infections

Drug resistance of medically relevant microorganisms poses a grave threat to human health and has severe economic consequences. Fungal pathogens pose an additional complication as they are closely related to their human host. Current therapies to treat fungal infections are limited and drug resistance has already emerged in the clinic. We have conducted extensive research on fungal drug resistance mechanisms and propose to target these mechanisms in combination with existing antifungals.

The effects of cannabinoids on vascular and cognitive function in young and old healthy adults

Cannabidiol (CBD) is a bioactive cannabinoid compound in marijuana (cannabis sativa), but unlike ?9 tetrahydrocannabinol (THC), lacks the psychoactivity effect of THC. Available evidence suggests that there are marked therapeutic CBD effects for diverse disease processes including inflammation, cancers, psychosis, and epileptic seizures. The purpose of this study, in both younger and older healthy humans, is to improve our understanding of how CBD might control and regulate blood vessel health as well as cognitive and exercise performance.

Development of a simulation model for prediction of performance of a novel positive airway pressure (PAP) machine for treatment of sleep apnea

The gold standard of treatment for patients with sleep apnea are Positive-airway-pressure (PAP) machines. PAPs provide a one-size-fits-all solution of providing the same therapy in terms of airflow to every patient and every breath. This causes frustration and discomfort for patients, therefore patients don’t purchase PAPs or purchase and don’t use them; leading to 4 times higher chances of stroke and 3 times higher chances of heart attacks as well as huge costs on the healthcare system.

The use of whole-body kinematic technology for optimizing current steering deep brain stimulation in Parkinson’s disease patients

Patients with advanced Parkinson’s disease (PD) may develop motor complications caused by Levodopa, the current drug used for treatment. Deep brain stimulation (DBS) is an alternative surgical treatment where electrodes are implanted in a specific brain region to deliver current to surrounding brain tissue which helps to alleviate motor symptoms of PD. Presently, there is a limitation to how the current is being delivered to the targeted brain region. Current steering (CS) is a novel DBS technique, unique to Boston Scientific systems, that accounts for this limitation.

Design and advancement of Graft Enabled Antibody Therapies (GrEAT) - Year 2

Membrane proteins such as ion channels, transporters or G-protein coupled receptors (GPCRs) are excellent but difficult drug targets involved in a large number of life-threatening diseases and conditions. These proteins, over-expressed and essential for disease onset and progression, are naturally targeted by toxins from venomous organisms. During evolution, these toxins have been optimized to efficiently target physiologically-relevant proteins involved in ion channel opening or closure, thus incapacitating the prey or defending against predators.

Improved veterinary diagnostics for tapeworms

Dogs can be infected with several species of tapeworms, but show no obvious symptoms. Tapeworms are generally diagnosed by detection of microscopic eggs produced by the parasites that are passed in the dog's stool. However, this technique is not ideal, as eggs are not always passed in stool, different tapeworms produce visually similar eggs, and this requires an experienced diagnostician. Therefore, false negatives are common. There is increasing interest in techniques to directly detect DNA of parasites in stool of dogs. Aquila Diagnostics Systems Inc.

Improving Productivity in Bioreactors through control of foaming and cell heterogeneity

Heterogeneity of cell populations is a common occurrence in bioreactor operations (Lara et al., 2006) and is typically caused by processing of cell cultures in vessels of varying sizes and process conditions and by deficient mixing. Most bioreactor research deals with average conditions of the cell population with respect to quantities such as dissolved oxygen and extracellular nutrient level, while these averages actually correspond to very different distributions of individual cell growth and productivity.

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