High throughput functional characterization of hereditary disease genes - ON-153

Preferred Disciplines: Cell Biology, Genetics, Molecular Biology (PhD or Post-Doc)
Company: Ranomics
Project Length: 4 months (1 unit per intern)
Desired start date: As soon as possible
Location: Toronto, ON
No. of Positions: 1-2
Preferences: University of Toronto

About the Company: 

Ranomics is a Toronto based biotech company developing novel genomics tools for improving drug discovery and utility. With a focus in creating innovative solutions for understand human genetic variation at scale, Ranomics is uniquely positioned for the development of next-generation tissue agnostic therapies. Founded in 2015, Ranomics is backed by leading life-science investors including SOS Ventures and was a recent graduate from JLabs Toronto. 

Project Description:

Ranomics is developing novel functional genomic tools for enabling rapid analysis of genetic variants in clinically relevant cell models. Towards this end, Ranomics is establishing high-throughput assay systems for a number of hereditary disease genes across multiple clinical models. The objective of this research project is to establish and validate novel cell systems for high throughput genomics screening.

Research Objectives:

  • Identify relevent clinical cell models for genomics studies
  • Establish standard operating procedures for genetic manipulation of novel cell models
  • Establish and optimize assay conditions for genes of interest

Methodology:

  • TBD

Expertise and Skills Needed:

    • Recombinant DNA work
    • Cell and tissue culture expertise and skills, preferably with primary cancer cells
    • Flow cytometry
    • Soft skills: creative thinking; self-motivation and clear communication
    • Experience with bioinformatics preferred, but not required

    For more info or to apply to this applied research position, please

    1. Check your eligibility and find more information about open projects
    2. Interested students need to get the approval from their supervisor and send their CV along with a link to their supervisor’s university webpage by applying through the webform.
    Program: