BC Cancer Agency - Bioinformatics/ Computational Biology PDF Position

 

A post-doctoral position is available for a highly motivated bioinformatics expert to join our expanding translational cancer research group engaged in childhood cancer research. The position will be co-supervised by Dr. Poul Sorensen, Department of Molecular Oncology, BC Cancer Research Centre, and Dr. Ryan Morin, Genome Sciences Centre of the BC Cancer Agency. The research group is dedicated to uncovering the molecular basis of childhood cancers, particularly solid tumors, and identifying new diagnostic and predictive markers and developing new tools for assessing these in such diseases. Responsibilities include analyzing diverse sets of high throughput genomic data sets derived from childhood tumours for correlation with morphologic and clinical features including outcome data, recurrence and metastasis. Many of these datasets are available from public resources and collaborative research projects. The candidate will also have access to large data sets produced in-house from muhttp://molonc.bccrc.ca/sorensen-lab/ltiple pediatric tumour types. Specifically, the candidate will lead projects aimed at characterizing these tumour genomes first from a computational perspective and subsequently to identify biomarkers for downstream functional validation. The candidate will perform algorithmic and statistical analyses on whole genome and transcriptome shotgun sequencing (RNA-seq) data from the Illumina HiSeq platform and infer mutational profiles to uncover etiological and evolutionary processes governing tumor biology, and potential targets for therapeutic intervention.

A Ph.D. degree in Bioinformatics, Biostatistics, Computer Sciences or a related field, and working experience with Unix/Linux, programming/scripting, R and SQL/relational databases as well as familiarity with next generation sequencing analysis tools are required.  Familiarity with human genome databases such as Ensembl, the UCSC genome browser, and NCBI is essential. Direct experience using parallel/high-performance computing environments and bioinformatics resources such as Bioconductor, the Ensembl API, BioPerl/BioPython/BioJava and Galaxy are assets. It is highly preferred that the candidate will have an in-depth working knowledge of cancer biology and genetics. Excellent written and verbal communication skills, time management, and the ability to multi-task with attention-to-detail are required.  The successful candidate must work well independently and in a team setting. The successful candidate will take a leadership role, and collaborate in, the writing of manuscripts for publication and grant proposals.

All qualified candidates are encouraged to apply and should submit a curriculum vitae AND the names and contact information for three referees by e-mail to the Department of Molecular Oncology, BCCRC. E-mail: CareersMolOnc@bccrc.ca.  Please quote job number 2013PS01 in the subject line.  For further information please visit http://molonc.bccrc.ca/

The BC Cancer Agency (BCCA) is committed to reducing the incidence of cancer, reducing the mortality from cancer, and improving the quality of life of those living with cancer.  The BC Cancer Research Centre (BCCRC) conducts research into the causes and cures for cancer. BCCA is an agency of the Provincial Health Services Authority (PHSA) which plans, manages and evaluates specialty and province-wide health care services across BC. The PHSA is committed to employment equity and hires on the basis of merit. We encourage applications from all qualified individuals.