Mass spectrometry for multiplexed high throughput analysis of large molecules

Whether it is for research, development or diagnostics, life sciences typically require the quantitation and characterization of samples with assays that classically measure molecules one at a time. Considering that the development and execution of such assays are time consuming and requires considerable investment, the uses of multiplexed analysis would be highly advantageous. Mass spectrometry is a technology that allows multiplexing, but requires highly specialized knowledge in order to achieve the desired results.

Molecular modeling module of the pharmaceutical platform technology

Pharmaceutical platform technology (PPT) was invented by Sinoveda Inc., the partner organization, to accomplish the tasks of identification, purification, and activity determination for the active ingredients of natural herbal remedies, with the goal of developing and optimizing the remedies. However, two issues remain to be tackled in the PPT process: first, there is as yet no systematic approach to take advantage of the properties of the ingredients of herbs; and second, there is a lack of appropriate methods to consistently understand their effects.

Calcium supplements, elemental bioavailability, and uptake by bone (Part 2)

There is an increasing number and variety of calcium supplements being made available to the Canadian public, often making claims regarding improved action over competitor products. The purpose of this project is to evaluate the effects of drugs and nutraceuticals upon bone health, particularly if they contain elements (such as calcium) which incorporate into newly mineralizing bone.

Techna Nanotechnology cluster

The first successful clinical application of nanotechnology was the use of a nanoparticle container to deliver a drug to a tumour. That basic strategy of using a nanoparticle to carry a treatment or indicator molecule has a lot of potential, but requires continued research to determine the therapeutic effectiveness and potential toxicity of each container and payload combination. DLVR Therapeutics and Merrimack Pharmaceuticals focus on the development of nanotechnology-based chemotherapeutic and imaging agents.

Prevention of hearing loss by oral administration of the flavonoid-enriched fraction AF4

Flavonoids are polyphenolic compounds which give fruits and vegetables their bright colours. Habitual consumption of dietary flavonoids reduces the risk for neurodegenerative disorders such as Parkinson’s disease, stroke and Alzheimer’s disease. Pre-clinical studies performed using animal models for these disorders have convincingly demonstrated that flavonoids not only halt the pathological processes which cause neurodegeneration but also promote recovery after brain damage.

Research and Development of Automated Pluripotent Stem Cell Propagation

Stem cells are at the forefront of modern medicine and are expected to revolutionize both the human and veterinary healthcare industries. Currently, a major obstacle to the field is the time-consuming and costly technical time spent growing and maintaining various stem cell populations. The degree of contamination with non-stem cells, ability of the stem cells to thrive and grow, and quality of the stem cells depends largely on the skill of the technician.

Development and optimization of a polymer-lipiu urug ueiivCi y formulation for the peri-operative treatment of ovarian cancer

The goal of the current research is to design an injectable polymer-lipid (Pol.i) formulation to treat ovarian cancer. The PoLi drug delivery system is a hiocompatible and biodegradable, physically cross-linked gel that has the potential to provide dramatic improvements in the treatment of ovarian cancer. It is formulated as an injectable gel (all components are safe for humans) which is then loaaded with active chemotherapy drugs such as the commercially available paclitaxel.

Biologic Therapies in Rheumatoid Arthritis

This project will profile the use of new drugs of rheumatoid arthritis, in a population-based sample. Potential differences in the use of these agents will be examined to identify discrepancies in drug use patterns across demographics, which could be addressed through targeted strategies. Our proposal is timely in terms of increasing attention on the part of policy-makers regarding "better, more coordinated evaluation of drug safety and effectiveness" and targeted intitiatives to increase knowledge about the safety and effectiveness of drugs in population-based samples.

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