Development of Monoclonal Antibodies and Rapid Lateral Flow Test Kit for the Specific Detection of Streptococcus agalactiae

Streptococcus agalactiae (S. agalactiae) is a worldwide-distributed bacterium. It is a major infectious agent to humans, cattle and aquatic animals. The outbreak and prevalence of S. agalactiae in aquaculture has been reported in different countries as one of the major causes of mortality leading to serious economic losses and threatening the sound development of aquaculture. The current methods for detection of S. agalactiae are time-consuming and require specific equipment and technical training.

Sleep quality and weaning from mechanical ventilation: a physiological clinical study

In mechanically ventilated critically ill patients, sleep disruption may contribute to prolonged weaning leading to longer intensive care unit stay and hospital mortality. It was reported that sleep disruption affects the outcome of noninvasive ventilation and we hypothesize that it may also have an impact in mechanically ventilated patients on the weaning outcome.

Cannabis Access Regulations Study (CANARY)

The CANARY study is a patient-centered assessment of the impact of the regulatory changes regarding access to cannabis for medical purposes in Canada. The study is the first to offer patients? perspectives regarding their experience of access to medical cannabis after the implementation of the new federal regulations that have created a decentralized competitive
national market for medical cannabis through the licensing of commercial producers.

Development of peptide-based probes as imaging and targeting agents for glioblastoma therapy

Glioblastoma (GBM), the most aggressive primary brain tumors in adults, is feared for its near uniformly fatal prognosis. Due to its infiltrative nature, surgery alone is ineffective in disease eradication. We originally identified abnormal cancer stem cells called brain tumor-initiating cells (BTICs) that lead to the formation of this brain tumor. These BTICs are known to be resistant to current chemoradiotherapy and act as disease reservoirs that contribute to recurrence. Using clinically relevant human GBM BTIC models from treatment resistant recurrent tumors, our collaborator Dr.

Hybrid journalism in the context of antipsychotic treatments for neurodevelopmental disabilities

Media reports on socially and biologically complex neurological conditions such as autism and fetal alcohol syndrome (FAS) often fail to engage audiences in meaningful discourse. Research is needed to identify new models of scientific reporting in journalism to counteract this gap. Our goal is to investigate and analyze a new model of science reporting that combines traditional and non-traditional approaches to effectively communicate complex scientific findings about treatments for autism and FAS.

Role of Nlrs in neurodegenerative diseases (New)

Nlrx1, belongs to NLR family of intracellular sensors that regulate mayor cellular pathway including cell death and inflammation. Previous research implicated Nlrx1 in regulation of autophagy and reactive oxygen species production during viral infection. In addition most recent publication implicated Nlrx1 in regulation of the cell death in fibroblasts cultures. Our preliminary data show that Nlrx1-/- mice are more prone to develop experimental autoimmune encephalomyelitis.

Structural and Functional Investigation of Disrupted in Schizophrenia 1 (DISC1)

The research project involves investigating the structure and function of DISC1 subdomains. As DISC1 is a large protein with multiple functions, breaking it down into its subdomains will facilitate our understanding of its biology. The biochemical and biophysical properties of subdomains will be characterized. This 12-week project will allow the student to learn how to use a state-of-the-art protein chromatography system to produce large quantity of proteins needed for downstream structural biological investigation.

Functional analysis of candidate genes in encephalitogenic T cell responses.

Multiple sclerosis (MS) is a chronic degenerative disease in which central nervous system demyelination and white matter inflammation leads to axonal injury and neurological deficit. Canada has one of the highest rates of MS incidence in the world; studying the pathogenesis of MS is of the utmost importance.

The impact of climate change on maternal-child health in Canada

Climate change is a fairly new phenomenon and its impact on health is poorly understood. Extreme weather events are becoming increasingly common, but the effect on vulnerable populations such as women and children is largely unknown. One particular problem that limits research on the impacts of extreme weather on health is the lack of indicators to help define extreme weather.

Perioperative use of opioids and risk of ovarian cancer recurrence and metastasis

Objective. The primary objective of this cohort study is to determine if use of opioids increases the risk of ovarian cancer recurrence and metastasis.