The use of improved antibody drug conjugates for targeted treatment of bladder cancer - Year two

Bladder cancer is the fifth most common form of cancer in Canada, however progress in the development of safer and more effective therapies has been slow. The use of antibody drug conjugates (ADC) is a promising therapeutic option that would allow for targeted killing of cancer cells, if the obstacle of getting the drug inside the cell can be overcome. The proposed research project aims to use iProgen's Antibody Internalization Domain technology to engineer ADCs targeted to bladder cancer, which can be readily taken into the cell.

Targeting CD36 cell surface receptor to treat macrophage-induced chronic inflammation

Chronic inflammation is the common denominator for various diseases, including atherosclerosis, age-related macular degeneration (AMD), obesity, type-2 diabetes, liver diseases and even cancers. In most cases, this inflammation is the result of massive pro-inflammatory macrophage infiltration in tissues, due to their aberrant signalling and dysfunction, in presence of fat accumulation. The CD36 scavenger receptor has been shown to be key player in inflammation, with its TLR2 co-receptor.

A study on the reliability of quantitative measures of the visual system and their correlation with change in concussion-associated symptoms

This project will determine if abnormal behavior of the visual system correlates with symptoms in patients with concussions. Our first step will be to ensure that we obtain the same values for each of 7 tests when we measure a healthy person twice within a short period of time (called reliability). Next, we will see the how changes in the seven different measures of the visual system over time correlate with changes in patients’ post-concussion symptoms over time.

Real Time Inverse Scattering for Optical Coherence Tomography

A critical challenge today in neuro-surgery is the determination of tumor boundaries intraoperatively. There are means of doing this using high-resolution MRI machines, however, these can be prohibitively costly. Optical coherence tomography (OCT) offers a promising, cheaper, label-free alternative. However, the basic models used for clinical, real-time OCT limit its usefulness and depth of focus. This work will develop a type of image reconstruction that includes digital focusing and anisotropic properties.

Cognitive Impairment Secondary to Depressive Symptomology and its Relationship with Functional Impairment

Depression is a disabling condition affecting millions of people. Some of the symptoms of depression make it impossible for people to function in their daily lives. People experience significant levels of memory, thinking, planning and other cognitive symptoms that impair their abilities to go to work, school and take care of themselves and family. What is unclear is how and to what extent does this type of impairment lead to real world disability, and whether or not these levels of impairment exist in a broad range of people with varying levels of depressive symptomology.

Targeting clonal heterogeneity in treatment-refractory Glioblastoma with novel and empiric immunotherapies

Glioblastoma (GBM) is the most common primary adult brain tumor, characterized by extensive cellular and genetic heterogeneity. Even with surgery, standard chemotherapy, and radiation, tumor recurrence and patient relapse are inevitable with a median survival rate of

Desvenlafaxine in Opioid-Dependent Patients

Patients who suffer from addiction to opioids often experience depression. Furthermore, data concerning the use of effective medication to treat depression in patients addicted to opioids is insufficient. Desvenlafaxine is an antidepressant that has been approved in Canada to treat depression within the general population.

Characterization of the antifibrotic efficacy of PBI-4050 in AdTGF-?1 mediated pulmonary fibrosis

Fibroproliferative disorders are a/the leading cause of morbidity and mortality worldwide. A large group of interstitial lung diseases (ILD) can cause progressive scarring of lung tissues, affecting the ability to breathe. Idiopathic Pulmonary Fibrosis (IPF) is one of the major forms of ILD and is characterized by a progressive decline in lung function. Although the pathogenesis of IPF is incompletely understood, work from our group and others suggest that transforming growth factor beta 1 (TGF-?1) is involved in the fibrogenic process.

Think-Move-Play: Towards personal health and rehabilitation monitoring using wearable devices

The Think-Move-Play project's purpose is to study the feasibility and acceptability of utilizing smart insoles to collect health information and interact with patients suffering from hip fracture and neurological diseases. We propose a unique solution by combining personal health monitoring and coaching that is augmented with a virtual play environment aimed to maintain constant high level of motivation.

Blood biomarkers of asthma

Allergic asthma is a condition of the airways characterized by airway constriction and hyperresponsiveness upon allergen exposure. About half of the allergic asthmatic individuals experience only an acute airway constriction (early response) within several minutes upon exposure to allergen while the other half of individuals experience not only an acute airway constriction but also a chronic airway constriction plus inflammation (late response) within several hours after the allergen exposure. It is not clear why the late response is not developed in all sensitized individuals.