Adipocyte Dysfunction as a Cause of Obesity-Induced Pathophysiologies: Accelerated Cellular Impairments in Individuals of South Asian Descent

At similar levels of obesity, individuals of South Asian descent (SA) are at greater risk than individuals of European Caucasian (EC) descent for developing type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). We hypothesize that in SA individuals, the morphology and functions of individual fat cells within fat tissue are altered, such that they are enlarged, inflamed and express altered levels of proteins called adipokines, which induce insulin resistance at other body organs, leading to T2DM and CVD.

Improving the Nouse® Perceptual Vision Interface for Individuals who have a Physical Disability

Nouse® software technology is a unique Canadian patented technology that uses advanced Video Recognition algorithms to allow a computer user to operate a computer hands‐free using the nose )or any other part of the body). Essentially, the Nouse® allows an individual to use their nose as a mouse. Over the past 4 years, a partnership between the University of Ottawa, Bruyère Continuing Care and IVIM Inc. has been working on refining this technology to ensure it is suitable for a physically disabled population.

Enhanced Child Safety in Automobiles- Knowledge & Technology Transfer

This project was in partnership with AUTO21. The focus of the research project is to raise awareness and knowledge of the public about the importance of booster seats for children aged 4-9. The specific objective of the internship is to evaluate the impact of Canadian booster seat legislation on motor vehicle occupant fatalities and injuries, especially spinal cord injuries, amongst children aged 4-9.

Development of SCODA DNA Extraction for Forensics Applications.

Nucleic acid analysis in forensic science is a major focus for DNA‐based identification in case‐work samples. Approximately 5% ‐ 10% of samples are known to fail as a result of contaminants carrying through the purification process, or as a result of insufficient yield in the DNA extraction step. Whereas, most crime scene exhibits produce meaningful results, inhibitors, minute traces of DNA, degraded DNA, and environmental insults, reduce the investigative potential of some of the most crucial exhibits.

Weight Management in Morbidly Obese Patients

Our objective is to examine the physical and behavioral characteristics of severely obese patients at the Wharton weight management clinic. We will utilize the patient records at enrollment to characterize this cohort, and administer additional questionnaires that are not routinely given by the clinic that will be completed by patients on a voluntary basis. During the internship, the students will be trained to conduct some of the baseline assessments at the first patient visit.

Investigating methods of long-term follow-up for patients with Metabolic Syndrome

This project was in partnership with the Canadian Obesity Network. Providence Healthcare has estrablished a reputation as one of the leading centres for cardiovascular research and treatment in Canada. Providence Healthcare and AstraZeneca, a research-based pharmaceutical company, are interested in furthering science and improve patient outcomes. The purpose of this study is to determine the best method of long term follow up for patients with Metabolic Syndrome once they have completed an intensive lifestyle modification program.

Apoptosis as a Mechanism for Delayed Engraftment in Cryopreserved Peripheral Blood Stem Cell Transplants

High dose chemotherapy treatment for lymphoma is followed by the infusion of patients’ own bloodforming stem cells to restore the function of the bone marrow. Canada Blood Services provides critical support in processing and storing these essential stem cell products at very low temperatures. On occasion, the recovery of blood cells after the transplant is delayed, increasing the risk of infections and bleeding complications. In many cases, it is not known why there is delayed engraftment.

Developing stochastic model of cognitive function in elderly persons

Cognitive function changes as people age, and for the most part, these changes are not for the good. Not everybody declines with the same rate; however, even people with cognitive impairment can experience different degree of decline. It is also known that a significant proportion of people can remain stable for a time or even improve. The previous statistical and analytical techniques mainly ignored these cases or considered them as diagnosis misclassifications or measurement errors, or insignificant fluctuation.

Does Endovascular Coiling of Posterior Communicating Artery Aneurysms Result in

Preventing a brain aneurysm from bleeding is an important minimally invasive procedure. It involves specialized training to develop skills in manipulating a tiny tube from the groin artery into the brain. This is performed using highly specialized imaging/X-ray equipment. Once the tube is guided into the brain aneurysm, small coils are positioned within the aneurysm to prevent it from bleeding. The goal of this internship is to investigate the efficacy of this technique in treating one of the most common types of brain aneurysms located at the posterior communicating artery.

Whole Genome Association Strategy for Unbiased Candidate Gene Selection in Inflammatory Diseases

Susceptible individuals for inflammatory diseases could be targeted for either preventative measures or care if we could identify them by obtaining their genetic code. However, to date, there is no effective method of discovering which of the more than 5 million genetic variants are important in determining disease susceptibility. A common approach is to test every genetic variation, in every patient, for its correlation with some disease (called Whole Genome Association orWGA), but this is extremely expensive and slow.

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